Shen A - Search Results

1

Allosteric regulation of protease activity by small molecules.

Shen A. Shen A. Mol Biosyst. 2010 Aug;6(8):1431-43. doi: 10.1039/c003913f. Epub 2010 Jun 10. Mol Biosyst. 2010. PMID: 20539873 Free PMC article. Review.

2

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins.

Shen A, Lupardus PJ, Gersch MM, Puri AW, Albrow VE, Garcia KC, Bogyo M. Shen A, et al. Nat Struct Mol Biol. 2011 Mar;18(3):364-71. doi: 10.1038/nsmb.1990. Epub 2011 Feb 13. Nat Struct Mol Biol. 2011. PMID: 21317893 Free PMC article.

3

Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain.

Lupardus PJ, Shen A, Bogyo M, Garcia KC. Lupardus PJ, et al. Among authors: shen a. Science. 2008 Oct 10;322(5899):265-8. doi: 10.1126/science.1162403. Science. 2008. PMID: 18845756 Free PMC article.

4

Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin.

Shen A, Lupardus PJ, Albrow VE, Guzzetta A, Powers JC, Garcia KC, Bogyo M. Shen A, et al. Nat Chem Biol. 2009 Jul;5(7):469-78. doi: 10.1038/nchembio.178. Nat Chem Biol. 2009. PMID: 19465933 Free PMC article.

5

Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors.

Ponder EL, Albrow VE, Leader BA, Békés M, Mikolajczyk J, Fonović UP, Shen A, Drag M, Xiao J, Deu E, Campbell AJ, Powers JC, Salvesen GS, Bogyo M. Ponder EL, et al. Among authors: shen a. Chem Biol. 2011 Jun 24;18(6):711-21. doi: 10.1016/j.chembiol.2011.04.010. Chem Biol. 2011. PMID: 21700207 Free PMC article.

6

Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB.

Puri AW, Lupardus PJ, Deu E, Albrow VE, Garcia KC, Bogyo M, Shen A. Puri AW, et al. Among authors: shen a. Chem Biol. 2010 Nov 24;17(11):1201-11. doi: 10.1016/j.chembiol.2010.09.011. Chem Biol. 2010. PMID: 21095570 Free PMC article.

7

Autoproteolytic activation of bacterial toxins.

Shen A. Shen A. Toxins (Basel). 2010 May;2(5):963-77. doi: 10.3390/toxins2050963. Epub 2010 May 6. Toxins (Basel). 2010. PMID: 22069620 Free PMC article. Review.

8

Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.

Puri AW, Broz P, Shen A, Monack DM, Bogyo M. Puri AW, et al. Among authors: shen a. Nat Chem Biol. 2012 Sep;8(9):745-7. doi: 10.1038/nchembio.1023. Epub 2012 Jul 15. Nat Chem Biol. 2012. PMID: 22797665 Free PMC article.

9

A small-molecule antivirulence agent for treating Clostridium difficile infection.

Bender KO, Garland M, Ferreyra JA, Hryckowian AJ, Child MA, Puri AW, Solow-Cordero DE, Higginbottom SK, Segal E, Banaei N, Shen A, Sonnenburg JL, Bogyo M. Bender KO, et al. Among authors: shen a. Sci Transl Med. 2015 Sep 23;7(306):306ra148. doi: 10.1126/scitranslmed.aac9103. Epub 2015 Sep 23. Sci Transl Med. 2015. PMID: 26400909 Free PMC article.

10

Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag.

Shen A, Lupardus PJ, Morell M, Ponder EL, Sadaghiani AM, Garcia KC, Bogyo M. Shen A, et al. PLoS One. 2009 Dec 2;4(12):e8119. doi: 10.1371/journal.pone.0008119. PLoS One. 2009. PMID: 19956581 Free PMC article.

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