Mead RJ - Search Results

1

Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy.

Valori CF, Ning K, Wyles M, Mead RJ, Grierson AJ, Shaw PJ, Azzouz M. Valori CF, et al. Among authors: mead rj. Sci Transl Med. 2010 Jun 9;2(35):35ra42. doi: 10.1126/scitranslmed.3000830. Sci Transl Med. 2010. PMID: 20538619

2

Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen.

Wood-Allum CA, Barber SC, Kirby J, Heath P, Holden H, Mead R, Higginbottom A, Allen S, Beaujeux T, Alexson SE, Ince PG, Shaw PJ. Wood-Allum CA, et al. Brain. 2006 Jul;129(Pt 7):1693-709. doi: 10.1093/brain/awl118. Epub 2006 May 15. Brain. 2006. PMID: 16702190

3

Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target.

Barber SC, Mead RJ, Shaw PJ. Barber SC, et al. Among authors: mead rj. Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1051-67. doi: 10.1016/j.bbadis.2006.03.008. Epub 2006 Apr 4. Biochim Biophys Acta. 2006. PMID: 16713195 Free article. Review.

4

An in vitro screening cascade to identify neuroprotective antioxidants in ALS.

Barber SC, Higginbottom A, Mead RJ, Barber S, Shaw PJ. Barber SC, et al. Among authors: mead rj. Free Radic Biol Med. 2009 Apr 15;46(8):1127-38. doi: 10.1016/j.freeradbiomed.2009.01.019. Epub 2009 Jan 30. Free Radic Biol Med. 2009. PMID: 19439221 Free PMC article.

5

Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).

Mead RJ, Bennett EJ, Kennerley AJ, Sharp P, Sunyach C, Kasher P, Berwick J, Pettmann B, Battaglia G, Azzouz M, Grierson A, Shaw PJ. Mead RJ, et al. PLoS One. 2011;6(8):e23244. doi: 10.1371/journal.pone.0023244. Epub 2011 Aug 18. PLoS One. 2011. PMID: 21876739 Free PMC article.

6

S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis.

Mead RJ, Higginbottom A, Allen SP, Kirby J, Bennett E, Barber SC, Heath PR, Coluccia A, Patel N, Gardner I, Brancale A, Grierson AJ, Shaw PJ. Mead RJ, et al. Free Radic Biol Med. 2013 Aug;61:438-52. doi: 10.1016/j.freeradbiomed.2013.04.018. Epub 2013 Apr 19. Free Radic Biol Med. 2013. PMID: 23608463 Free PMC article.

7

Early detection of motor dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis (ALS) using home cage running wheels.

Bennett EJ, Mead RJ, Azzouz M, Shaw PJ, Grierson AJ. Bennett EJ, et al. Among authors: mead rj. PLoS One. 2014 Sep 30;9(9):e107918. doi: 10.1371/journal.pone.0107918. eCollection 2014. PLoS One. 2014. PMID: 25268710 Free PMC article.

8

Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis.

Ciervo Y, Ning K, Jun X, Shaw PJ, Mead RJ. Ciervo Y, et al. Among authors: mead rj. Mol Neurodegener. 2017 Nov 13;12(1):85. doi: 10.1186/s13024-017-0227-3. Mol Neurodegener. 2017. PMID: 29132389 Free PMC article. Review.

9

Adipose-derived stem cells protect motor neurons and reduce glial activation in both in vitro and in vivo models of ALS.

Ciervo Y, Gatto N, Allen C, Grierson A, Ferraiuolo L, Mead RJ, Shaw PJ. Ciervo Y, et al. Among authors: mead rj. Mol Ther Methods Clin Dev. 2021 Mar 27;21:413-433. doi: 10.1016/j.omtm.2021.03.017. eCollection 2021 Jun 11. Mol Ther Methods Clin Dev. 2021. PMID: 33869658 Free PMC article.

10

In Vivo Fiber Optic Raman Spectroscopy of Muscle in Preclinical Models of Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy.

Plesia M, Stevens OA, Lloyd GR, Kendall CA, Coldicott I, Kennerley AJ, Miller G, Shaw PJ, Mead RJ, Day JCC, Alix JJP. Plesia M, et al. Among authors: mead rj. ACS Chem Neurosci. 2021 May 19;12(10):1768-1776. doi: 10.1021/acschemneuro.0c00794. Epub 2021 May 5. ACS Chem Neurosci. 2021. PMID: 33950665 Free PMC article.

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