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A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release.
Yang H, Hreggvidsdottir HS, Palmblad K, Wang H, Ochani M, Li J, Lu B, Chavan S, Rosas-Ballina M, Al-Abed Y, Akira S, Bierhaus A, Erlandsson-Harris H, Andersson U, Tracey KJ. Yang H, et al. Among authors: chavan s. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11942-7. doi: 10.1073/pnas.1003893107. Epub 2010 Jun 14. Proc Natl Acad Sci U S A. 2010. PMID: 20547845 Free PMC article.
Inhibition of high-mobility group box 1 protein (HMGB1) enhances bacterial clearance and protects against Pseudomonas Aeruginosa pneumonia in cystic fibrosis.
Entezari M, Weiss DJ, Sitapara R, Whittaker L, Wargo MJ, Li J, Wang H, Yang H, Sharma L, Phan BD, Javdan M, Chavan SS, Miller EJ, Tracey KJ, Mantell LL. Entezari M, et al. Among authors: chavan ss. Mol Med. 2012 May 9;18(1):477-85. doi: 10.2119/molmed.2012.00024. Mol Med. 2012. PMID: 22314397 Free PMC article.
Novel role of PKR in inflammasome activation and HMGB1 release.
Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ. Lu B, et al. Among authors: chavan ss. Nature. 2012 Aug 30;488(7413):670-4. doi: 10.1038/nature11290. Nature. 2012. PMID: 22801494 Free PMC article.
High Mobility Group Box-1 mediates hyperoxia-induced impairment of Pseudomonas aeruginosa clearance and inflammatory lung injury in mice.
Patel VS, Sitapara RA, Gore A, Phan B, Sharma L, Sampat V, Li JH, Yang H, Chavan SS, Wang H, Tracey KJ, Mantell LL. Patel VS, et al. Among authors: chavan ss. Am J Respir Cell Mol Biol. 2013 Mar;48(3):280-7. doi: 10.1165/rcmb.2012-0279OC. Epub 2012 Oct 18. Am J Respir Cell Mol Biol. 2013. PMID: 23087050 Free PMC article.
JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation.
Lu B, Antoine DJ, Kwan K, Lundbäck P, Wähämaa H, Schierbeck H, Robinson M, Van Zoelen MA, Yang H, Li J, Erlandsson-Harris H, Chavan SS, Wang H, Andersson U, Tracey KJ. Lu B, et al. Among authors: chavan ss. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3068-73. doi: 10.1073/pnas.1316925111. Epub 2014 Jan 27. Proc Natl Acad Sci U S A. 2014. PMID: 24469805 Free PMC article.
697 results