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PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.
Poulogiannis G, McIntyre RE, Dimitriadi M, Apps JR, Wilson CH, Ichimura K, Luo F, Cantley LC, Wyllie AH, Adams DJ, Arends MJ. Poulogiannis G, et al. Among authors: mcintyre re. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15145-50. doi: 10.1073/pnas.1009941107. Epub 2010 Aug 9. Proc Natl Acad Sci U S A. 2010. PMID: 20696900 Free PMC article.
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.
Crossan GP, van der Weyden L, Rosado IV, Langevin F, Gaillard PHL, McIntyre RE; Sanger Mouse Genetics Project; Gallagher F, Kettunen MI, Lewis DY, Brindle K, Arends MJ, Adams DJ, Patel KJ. Crossan GP, et al. Among authors: mcintyre re. Nat Genet. 2011 Feb;43(2):147-52. doi: 10.1038/ng.752. Epub 2011 Jan 16. Nat Genet. 2011. PMID: 21240276 Free PMC article.
Mouse genomic variation and its effect on phenotypes and gene regulation.
Keane TM, Goodstadt L, Danecek P, White MA, Wong K, Yalcin B, Heger A, Agam A, Slater G, Goodson M, Furlotte NA, Eskin E, Nellåker C, Whitley H, Cleak J, Janowitz D, Hernandez-Pliego P, Edwards A, Belgard TG, Oliver PL, McIntyre RE, Bhomra A, Nicod J, Gan X, Yuan W, van der Weyden L, Steward CA, Bala S, Stalker J, Mott R, Durbin R, Jackson IJ, Czechanski A, Guerra-Assunção JA, Donahue LR, Reinholdt LG, Payseur BA, Ponting CP, Birney E, Flint J, Adams DJ. Keane TM, et al. Among authors: mcintyre re. Nature. 2011 Sep 14;477(7364):289-94. doi: 10.1038/nature10413. Nature. 2011. PMID: 21921910 Free PMC article.
The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation.
Nijnik A, Clare S, Hale C, Raisen C, McIntyre RE, Yusa K, Everitt AR, Mottram L, Podrini C, Lucas M, Estabel J, Goulding D; Sanger Institute Microarray Facility; Sanger Mouse Genetics Project; Adams N, Ramirez-Solis R, White JK, Adams DJ, Hancock RE, Dougan G. Nijnik A, et al. Among authors: mcintyre re. Blood. 2012 Feb 9;119(6):1370-9. doi: 10.1182/blood-2011-05-352666. Epub 2011 Dec 19. Blood. 2012. PMID: 22184403 Free article.
Cancer gene discovery in the mouse.
McIntyre RE, van der Weyden L, Adams DJ. McIntyre RE, et al. Curr Opin Genet Dev. 2012 Feb;22(1):14-20. doi: 10.1016/j.gde.2011.12.003. Epub 2012 Jan 20. Curr Opin Genet Dev. 2012. PMID: 22265936 Review.
Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity.
van der Weyden L, Rust AG, McIntyre RE, Robles-Espinoza CD, del Castillo Velasco-Herrera M, Strogantsev R, Ferguson-Smith AC, McCarthy S, Keane TM, Arends MJ, Adams DJ. van der Weyden L, et al. Among authors: mcintyre re. Oncogene. 2013 Jan 17;32(3):397-402. doi: 10.1038/onc.2012.56. Epub 2012 Feb 27. Oncogene. 2013. PMID: 22370638 Free PMC article.
Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.
Wilson CH, Crombie C, van der Weyden L, Poulogiannis G, Rust AG, Pardo M, Gracia T, Yu L, Choudhary J, Poulin GB, McIntyre RE, Winton DJ, March HN, Arends MJ, Fraser AG, Adams DJ. Wilson CH, et al. Among authors: mcintyre re. EMBO J. 2012 May 30;31(11):2486-97. doi: 10.1038/emboj.2012.91. Epub 2012 Apr 17. EMBO J. 2012. PMID: 22510880 Free PMC article.
39 results