Ghosh AK - Search Results

1

Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation.

Ghosh AK, Takayama J, Rao KV, Ratia K, Chaudhuri R, Mulhearn DC, Lee H, Nichols DB, Baliji S, Baker SC, Johnson ME, Mesecar AD. Ghosh AK, et al. J Med Chem. 2010 Jul 8;53(13):4968-79. doi: 10.1021/jm1004489. J Med Chem. 2010. PMID: 20527968 Free PMC article.

2

Structure-based design of HIV-1 protease inhibitors: replacement of two amides and a 10 pi-aromatic system by a fused bis-tetrahydrofuran.

Ghosh AK, Thompson WJ, Fitzgerald PM, Culberson JC, Axel MG, McKee SP, Huff JR, Anderson PS. Ghosh AK, et al. J Med Chem. 1994 Aug 5;37(16):2506-8. doi: 10.1021/jm00042a002. J Med Chem. 1994. PMID: 8057296 No abstract available.

3

The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors.

Ghosh AK, Lee HY, Thompson WJ, Culberson C, Holloway MK, McKee SP, Munson PM, Duong TT, Smith AM, Darke PL, et al. Ghosh AK, et al. J Med Chem. 1994 Apr 15;37(8):1177-88. doi: 10.1021/jm00034a016. J Med Chem. 1994. PMID: 8164260

4

Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands.

Ghosh AK, Thompson WJ, Holloway MK, McKee SP, Duong TT, Lee HY, Munson PM, Smith AM, Wai JM, Darke PL, et al. Ghosh AK, et al. J Med Chem. 1993 Aug 6;36(16):2300-10. doi: 10.1021/jm00068a006. J Med Chem. 1993. PMID: 8360874

5

3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors.

Ghosh AK, Thompson WJ, McKee SP, Duong TT, Lyle TA, Chen JC, Darke PL, Zugay JA, Emini EA, Schleif WA, et al. Ghosh AK, et al. J Med Chem. 1993 Jan 22;36(2):292-4. doi: 10.1021/jm00054a015. J Med Chem. 1993. PMID: 8423600 No abstract available.

6

Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors.

Ghosh AK, Thompson WJ, Lee HY, McKee SP, Munson PM, Duong TT, Darke PL, Zugay JA, Emini EA, Schleif WA, et al. Ghosh AK, et al. J Med Chem. 1993 Apr 2;36(7):924-7. doi: 10.1021/jm00059a019. J Med Chem. 1993. PMID: 8464047 No abstract available.

7

Nonpeptidal P2 ligands for HIV protease inhibitors: structure-based design, synthesis, and biological evaluation.

Ghosh AK, Kincaid JF, Walters DE, Chen Y, Chaudhuri NC, Thompson WJ, Culberson C, Fitzgerald PM, Lee HY, McKee SP, Munson PM, Duong TT, Darke PL, Zugay JA, Schleif WA, Axel MG, Lin J, Huff JR. Ghosh AK, et al. J Med Chem. 1996 Aug 16;39(17):3278-90. doi: 10.1021/jm960128k. J Med Chem. 1996. PMID: 8765511

8

Structure based design: novel spirocyclic ethers as nonpeptidal P2-ligands for HIV protease inhibitors.

Ghosh AK, Krishnan K, Walters DE, Cho W, Cho H, Koo Y, Trevino J, Holland L, Buthod J. Ghosh AK, et al. Bioorg Med Chem Lett. 1998 Apr 21;8(8):979-82. doi: 10.1016/s0960-894x(98)00139-5. Bioorg Med Chem Lett. 1998. PMID: 9871524

9

Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.

Ghosh AK, Kincaid JF, Cho W, Walters DE, Krishnan K, Hussain KA, Koo Y, Cho H, Rudall C, Holland L, Buthod J. Ghosh AK, et al. Bioorg Med Chem Lett. 1998 Mar 17;8(6):687-90. doi: 10.1016/s0960-894x(98)00098-5. Bioorg Med Chem Lett. 1998. PMID: 9871583

10

Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase).

Ghosh AK, Bilcer G, Harwood C, Kawahama R, Shin D, Hussain KA, Hong L, Loy JA, Nguyen C, Koelsch G, Ermolieff J, Tang J. Ghosh AK, et al. J Med Chem. 2001 Aug 30;44(18):2865-8. doi: 10.1021/jm0101803. J Med Chem. 2001. PMID: 11520194

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