Baker SC - Search Results

1

Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation.

Ghosh AK, Takayama J, Rao KV, Ratia K, Chaudhuri R, Mulhearn DC, Lee H, Nichols DB, Baliji S, Baker SC, Johnson ME, Mesecar AD. Ghosh AK, et al. Among authors: baker sc. J Med Chem. 2010 Jul 8;53(13):4968-79. doi: 10.1021/jm1004489. J Med Chem. 2010. PMID: 20527968 Free PMC article.

2

Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.

Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD. Ghosh AK, et al. Among authors: baker sc. J Med Chem. 2005 Nov 3;48(22):6767-71. doi: 10.1021/jm050548m. J Med Chem. 2005. PMID: 16250632

3

Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors.

Ghosh AK, Xi K, Grum-Tokars V, Xu X, Ratia K, Fu W, Houser KV, Baker SC, Johnson ME, Mesecar AD. Ghosh AK, et al. Among authors: baker sc. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5876-80. doi: 10.1016/j.bmcl.2007.08.031. Epub 2007 Aug 19. Bioorg Med Chem Lett. 2007. PMID: 17855091 Free PMC article.

4

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors.

Ghosh AK, Gong G, Grum-Tokars V, Mulhearn DC, Baker SC, Coughlin M, Prabhakar BS, Sleeman K, Johnson ME, Mesecar AD. Ghosh AK, et al. Among authors: baker sc. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8. doi: 10.1016/j.bmcl.2008.08.082. Epub 2008 Aug 28. Bioorg Med Chem Lett. 2008. PMID: 18796354 Free PMC article.

5

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.

Ratia K, Pegan S, Takayama J, Sleeman K, Coughlin M, Baliji S, Chaudhuri R, Fu W, Prabhakar BS, Johnson ME, Baker SC, Ghosh AK, Mesecar AD. Ratia K, et al. Among authors: baker sc. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24. doi: 10.1073/pnas.0805240105. Epub 2008 Oct 13. Proc Natl Acad Sci U S A. 2008. PMID: 18852458 Free PMC article.

6

Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease.

Ghosh AK, Takayama J, Aubin Y, Ratia K, Chaudhuri R, Baez Y, Sleeman K, Coughlin M, Nichols DB, Mulhearn DC, Prabhakar BS, Baker SC, Johnson ME, Mesecar AD. Ghosh AK, et al. Among authors: baker sc. J Med Chem. 2009 Aug 27;52(16):5228-40. doi: 10.1021/jm900611t. J Med Chem. 2009. PMID: 19645480 Free PMC article.

7

Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy.

Ghosh AK, Xi K, Johnson ME, Baker SC, Mesecar AD. Ghosh AK, et al. Among authors: baker sc. Annu Rep Med Chem. 2007 Feb 1;41:183-196. doi: 10.1016/S0065-7743(06)41011-3. Annu Rep Med Chem. 2007. PMID: 19649165 Free PMC article.

8

X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases.

Báez-Santos YM, Barraza SJ, Wilson MW, Agius MP, Mielech AM, Davis NM, Baker SC, Larsen SD, Mesecar AD. Báez-Santos YM, et al. Among authors: baker sc. J Med Chem. 2014 Mar 27;57(6):2393-412. doi: 10.1021/jm401712t. Epub 2014 Mar 14. J Med Chem. 2014. PMID: 24568342 Free PMC article.

9

Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease.

Ratia K, Kilianski A, Baez-Santos YM, Baker SC, Mesecar A. Ratia K, et al. Among authors: baker sc. PLoS Pathog. 2014 May 22;10(5):e1004113. doi: 10.1371/journal.ppat.1004113. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24854014 Free PMC article.

10

The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity.

Barretto N, Jukneliene D, Ratia K, Chen Z, Mesecar AD, Baker SC. Barretto N, et al. Among authors: baker sc. J Virol. 2005 Dec;79(24):15189-98. doi: 10.1128/JVI.79.24.15189-15198.2005. J Virol. 2005. PMID: 16306590 Free PMC article.

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