Chen W - Search Results

1

Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.

Chen W, Chen M, Barak LS. Chen W, et al. Among authors: chen m. Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G293-300. doi: 10.1152/ajpgi.00005.2010. Epub 2010 May 27. Am J Physiol Gastrointest Liver Physiol. 2010. PMID: 20508156 Free PMC article. Review.

2

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

Chen M, Wang J, Lu J, Bond MC, Ren XR, Lyerly HK, Barak LS, Chen W. Chen M, et al. Among authors: chen w. Biochemistry. 2009 Nov 3;48(43):10267-74. doi: 10.1021/bi9009677. Biochemistry. 2009. PMID: 19772353 Free PMC article.

3

Small molecule modulators of Wnt/β-catenin signaling.

Mook RA Jr, Chen M, Lu J, Barak LS, Lyerly HK, Chen W. Mook RA Jr, et al. Among authors: chen m, chen w. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2187-91. doi: 10.1016/j.bmcl.2013.01.101. Epub 2013 Jan 30. Bioorg Med Chem Lett. 2013. PMID: 23453073 Free PMC article.

4

Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.

Mook RA Jr, Wang J, Ren XR, Chen M, Spasojevic I, Barak LS, Lyerly HK, Chen W. Mook RA Jr, et al. Among authors: chen m, chen w. Bioorg Med Chem. 2015 Sep 1;23(17):5829-38. doi: 10.1016/j.bmc.2015.07.001. Epub 2015 Aug 10. Bioorg Med Chem. 2015. PMID: 26272032 Free PMC article.

5

Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis.

Mook RA Jr, Ren XR, Wang J, Piao H, Barak LS, Kim Lyerly H, Chen W. Mook RA Jr, et al. Among authors: chen w. Bioorg Med Chem. 2017 Mar 15;25(6):1804-1816. doi: 10.1016/j.bmc.2017.01.046. Epub 2017 Feb 3. Bioorg Med Chem. 2017. PMID: 28233680 Free PMC article.

6

Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.

Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ. Chen W, et al. Science. 2003 Sep 5;301(5638):1391-4. doi: 10.1126/science.1082808. Science. 2003. PMID: 12958364

7

G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.

Chen M, Philipp M, Wang J, Premont RT, Garrison TR, Caron MG, Lefkowitz RJ, Chen W. Chen M, et al. Among authors: chen w. J Biol Chem. 2009 Dec 11;284(50):35040-8. doi: 10.1074/jbc.M109.047456. Epub 2009 Oct 2. J Biol Chem. 2009. PMID: 19801552 Free PMC article.

8

Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine.

Wang J, Lu J, Bond MC, Chen M, Ren XR, Lyerly HK, Barak LS, Chen W. Wang J, et al. Among authors: chen m, chen w. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9323-8. doi: 10.1073/pnas.0910712107. Epub 2010 May 3. Proc Natl Acad Sci U S A. 2010. PMID: 20439738 Free PMC article.

9

Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.

Osada T, Chen M, Yang XY, Spasojevic I, Vandeusen JB, Hsu D, Clary BM, Clay TM, Chen W, Morse MA, Lyerly HK. Osada T, et al. Among authors: chen m, chen w. Cancer Res. 2011 Jun 15;71(12):4172-82. doi: 10.1158/0008-5472.CAN-10-3978. Epub 2011 Apr 29. Cancer Res. 2011. PMID: 21531761 Free PMC article.

10

Glucocorticoid hedgehog agonists in neurogenesis.

Wang J, Barak LS, Mook RA Jr, Chen W. Wang J, et al. Among authors: chen w. Vitam Horm. 2011;87:207-15. doi: 10.1016/B978-0-12-386015-6.00030-5. Vitam Horm. 2011. PMID: 22127244 Free PMC article. Review.

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