Desilets A - Search Results

1

Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis.

Milner JM, Patel A, Davidson RK, Swingler TE, Desilets A, Young DA, Kelso EB, Donell ST, Cawston TE, Clark IM, Ferrell WR, Plevin R, Lockhart JC, Leduc R, Rowan AD. Milner JM, et al. Among authors: desilets a. Arthritis Rheum. 2010 Jul;62(7):1955-66. doi: 10.1002/art.27476. Arthritis Rheum. 2010. PMID: 20506309 Free article.

2

Inhibition of human matriptase by eglin c variants.

Désilets A, Longpré JM, Beaulieu ME, Leduc R. Désilets A, et al. FEBS Lett. 2006 Apr 17;580(9):2227-32. doi: 10.1016/j.febslet.2006.03.030. Epub 2006 Mar 20. FEBS Lett. 2006. PMID: 16566926 Free article.

3

Mutation G827R in matriptase causing autosomal recessive ichthyosis with hypotrichosis yields an inactive protease.

Désilets A, Béliveau F, Vandal G, McDuff FO, Lavigne P, Leduc R. Désilets A, et al. J Biol Chem. 2008 Apr 18;283(16):10535-42. doi: 10.1074/jbc.M707012200. Epub 2008 Feb 8. J Biol Chem. 2008. PMID: 18263585 Free PMC article.

4

Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides.

Béliveau F, Désilets A, Leduc R. Béliveau F, et al. Among authors: desilets a. FEBS J. 2009 Apr;276(8):2213-26. doi: 10.1111/j.1742-4658.2009.06950.x. Epub 2009 Mar 3. FEBS J. 2009. PMID: 19302215 Free article.

5

Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality.

Béliveau F, Brulé C, Désilets A, Zimmerman B, Laporte SA, Lavoie CL, Leduc R. Béliveau F, et al. Among authors: desilets a. J Biol Chem. 2011 Aug 19;286(33):29035-29043. doi: 10.1074/jbc.M111.223461. Epub 2011 Jul 1. J Biol Chem. 2011. PMID: 21724843 Free PMC article.

6

Matriptase protects against experimental colitis and promotes intestinal barrier recovery.

Netzel-Arnett S, Buzza MS, Shea-Donohue T, Désilets A, Leduc R, Fasano A, Bugge TH, Antalis TM. Netzel-Arnett S, et al. Among authors: desilets a. Inflamm Bowel Dis. 2012 Jul;18(7):1303-14. doi: 10.1002/ibd.21930. Epub 2011 Nov 13. Inflamm Bowel Dis. 2012. PMID: 22081509 Free PMC article.

7

Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway.

Buzza MS, Martin EW, Driesbaugh KH, Désilets A, Leduc R, Antalis TM. Buzza MS, et al. Among authors: desilets a. J Biol Chem. 2013 Apr 12;288(15):10328-37. doi: 10.1074/jbc.M112.443432. Epub 2013 Feb 26. J Biol Chem. 2013. PMID: 23443662 Free PMC article.

8

Design and synthesis of potent, selective inhibitors of matriptase.

Colombo E, Désilets A, Duchêne D, Chagnon F, Najmanovich R, Leduc R, Marsault E. Colombo E, et al. Among authors: desilets a. ACS Med Chem Lett. 2012 Apr 11;3(7):530-4. doi: 10.1021/ml3000534. eCollection 2012 Jul 12. ACS Med Chem Lett. 2012. PMID: 24900505 Free PMC article.

9

Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2.

Duchêne D, Colombo E, Désilets A, Boudreault PL, Leduc R, Marsault E, Najmanovich R. Duchêne D, et al. Among authors: desilets a. J Med Chem. 2014 Dec 11;57(23):10198-204. doi: 10.1021/jm5015633. Epub 2014 Nov 21. J Med Chem. 2014. PMID: 25387268

10

Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids.

St-Georges C, Désilets A, Béliveau F, Ghinet M, Dion SP, Colombo É, Boudreault PL, Najmanovich RJ, Leduc R, Marsault É. St-Georges C, et al. Among authors: desilets a. Eur J Med Chem. 2017 Mar 31;129:110-123. doi: 10.1016/j.ejmech.2017.02.006. Epub 2017 Feb 11. Eur J Med Chem. 2017. PMID: 28219045

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