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Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death.
Nabben M, van Bree BWJ, Lenaers E, Hoeks J, Hesselink MKC, Schaart G, Gijbels MJJ, Glatz JFC, da Silva GJJ, de Windt LJ, Tian R, Mike E, Skapura DG, Wehrens XHT, Schrauwen P. Nabben M, et al. Basic Res Cardiol. 2014;109(6):447. doi: 10.1007/s00395-014-0447-4. Epub 2014 Oct 25. Basic Res Cardiol. 2014. PMID: 25344084 Free PMC article.
Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperglycemia and hyperinsulinemia: a study in Zucker diabetic fatty rats.
Lenaers E, De Feyter HM, Hoeks J, Schrauwen P, Schaart G, Nabben M, Nicolay K, Prompers JJ, Hesselink MK. Lenaers E, et al. Among authors: nabben m. Obesity (Silver Spring). 2010 Jun;18(6):1100-7. doi: 10.1038/oby.2009.372. Epub 2009 Oct 29. Obesity (Silver Spring). 2010. PMID: 19875988 Free article.
Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity.
Timmers S, Nabben M, Bosma M, van Bree B, Lenaers E, van Beurden D, Schaart G, Westerterp-Plantenga MS, Langhans W, Hesselink MK, Schrauwen-Hinderling VB, Schrauwen P. Timmers S, et al. Among authors: nabben m. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11711-6. doi: 10.1073/pnas.1206868109. Epub 2012 Jul 2. Proc Natl Acad Sci U S A. 2012. PMID: 22753483 Free PMC article.
56 results