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Clinical trial: evaluation of gastric acid suppression with three doses of immediate-release esomeprazole in the fixed-dose combination of PN 400 (naproxen/esomeprazole magnesium) compared with naproxen 500 mg and enteric-coated esomeprazole 20 mg: a randomized, open-label, Phase I study in healthy volunteers.
Miner P Jr, Plachetka J, Orlemans E, Fort JG, Sostek M. Miner P Jr, et al. Among authors: sostek m. Aliment Pharmacol Ther. 2010 Aug;32(3):414-24. doi: 10.1111/j.1365-2036.2010.04361.x. Epub 2010 May 18. Aliment Pharmacol Ther. 2010. PMID: 20491746 Clinical Trial.
A fixed-dose combination of naproxen and esomeprazole magnesium has comparable upper gastrointestinal tolerability to celecoxib in patients with osteoarthritis of the knee: results from two randomized, parallel-group, placebo-controlled trials.
Cryer BL, Sostek MB, Fort JG, Svensson O, Hwang C, Hochberg MC. Cryer BL, et al. Ann Med. 2011 Dec;43(8):594-605. doi: 10.3109/07853890.2011.625971. Epub 2011 Oct 22. Ann Med. 2011. PMID: 22017620 Free article. Clinical Trial.
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