Generaux CN - Search Results

1

Application of monoclonal antibodies to measure metabolism of an anti-trypanosomal compound in vitro and in vivo.

Goldsmith RB, Gray DR, Yan Z, Generaux CN, Tidwell RR, Reisner HM. Goldsmith RB, et al. Among authors: generaux cn. J Clin Lab Anal. 2010;24(3):187-94. doi: 10.1002/jcla.20380. J Clin Lab Anal. 2010. PMID: 20486201 Free PMC article.

2

A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair.

Yan GZ, Generaux CN, Yoon M, Goldsmith RB, Tidwell RR, Hall JE, Olson CA, Clewell HJ, Brouwer KL, Paine MF. Yan GZ, et al. Among authors: generaux cn. Drug Metab Dispos. 2012 Jan;40(1):6-17. doi: 10.1124/dmd.111.040063. Epub 2011 Sep 27. Drug Metab Dispos. 2012. PMID: 21953913 Free PMC article. Clinical Trial.

3

Compartmental and enzyme kinetic modeling to elucidate the biotransformation pathway of a centrally acting antitrypanosomal prodrug.

Generaux CN, Ainslie GR, Bridges AS, Ismail MA, Boykin DW, Tidwell RR, Thakker DR, Paine MF. Generaux CN, et al. Drug Metab Dispos. 2013 Feb;41(2):518-28. doi: 10.1124/dmd.112.048231. Epub 2012 Dec 6. Drug Metab Dispos. 2013. PMID: 23223498 Free PMC article.

4

Diamidines for human African trypanosomiasis.

Paine MF, Wang MZ, Generaux CN, Boykin DW, Wilson WD, De Koning HP, Olson CA, Pohlig G, Burri C, Brun R, Murilla GA, Thuita JK, Barrett MP, Tidwell RR. Paine MF, et al. Among authors: generaux cn. Curr Opin Investig Drugs. 2010 Aug;11(8):876-83. Curr Opin Investig Drugs. 2010. PMID: 20721830 Review.

5

In vitro and in vivo determination of piperacillin metabolism in humans.

Ghibellini G, Bridges AS, Generaux CN, Brouwer KL. Ghibellini G, et al. Among authors: generaux cn. Drug Metab Dispos. 2007 Mar;35(3):345-9. doi: 10.1124/dmd.106.012278. Epub 2006 Dec 28. Drug Metab Dispos. 2007. PMID: 17194717 Clinical Trial.

6

Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.

Ismail MA, Arafa RK, Brun R, Wenzler T, Miao Y, Wilson WD, Generaux C, Bridges A, Hall JE, Boykin DW. Ismail MA, et al. J Med Chem. 2006 Aug 24;49(17):5324-32. doi: 10.1021/jm060470p. J Med Chem. 2006. PMID: 16913722

7

Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure.

Meng W, Pi Z, Brigance R, Rossi KA, Schumacher WA, Bostwick JS, Gargalovic PS, Onorato JM, Luk CE, Generaux CN, Wang T, Wexler RR, Finlay HJ. Meng W, et al. Among authors: generaux cn. J Med Chem. 2021 Dec 23;64(24):18102-18113. doi: 10.1021/acs.jmedchem.1c01504. Epub 2021 Dec 2. J Med Chem. 2021. PMID: 34855405

8

Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists.

Tora G, Jiang J, Bostwick JS, Gargalovic PS, Onorato JM, Luk CE, Generaux C, Xu C, Galella MA, Wang T, He Y, Wexler RR, Finlay HJ. Tora G, et al. Bioorg Med Chem Lett. 2021 Oct 15;50:128325. doi: 10.1016/j.bmcl.2021.128325. Epub 2021 Aug 14. Bioorg Med Chem Lett. 2021. PMID: 34403724

9

Identification of 6-Hydroxypyrimidin-4(1H)-one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists.

Pi Z, Johnson JA, Meng W, Phillips M, Schumacher WA, Bostwick JS, Gargalovic PS, Onorato JM, Generaux CN, Wang T, He Y, Gordon DA, Wexler RR, Finlay HJ. Pi Z, et al. Among authors: generaux cn. ACS Med Chem Lett. 2021 Oct 22;12(11):1766-1772. doi: 10.1021/acsmedchemlett.1c00385. eCollection 2021 Nov 11. ACS Med Chem Lett. 2021. PMID: 34795866 Free PMC article.

10

Design and preparation of N-linked hydroxypyridine-based APJ agonists.

Richter JM, Alex Bates J, Gargalovic P, Onorato JM, Generaux C, Wang T, Gordon DA, Wexler RR, Finlay HJ. Richter JM, et al. Bioorg Med Chem Lett. 2022 Oct 1;73:128882. doi: 10.1016/j.bmcl.2022.128882. Epub 2022 Jul 8. Bioorg Med Chem Lett. 2022. PMID: 35817293

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

18 results

Search Page

Filters