Wong CH - Search Results

1

Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors.

Shih HW, Chen KT, Chen SK, Huang CY, Cheng TJ, Ma C, Wong CH, Cheng WC. Shih HW, et al. Among authors: wong ch. Org Biomol Chem. 2010 Jun 7;8(11):2586-93. doi: 10.1039/c000622j. Epub 2010 Mar 29. Org Biomol Chem. 2010. PMID: 20485795

2

Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease.

Sawkar AR, Cheng WC, Beutler E, Wong CH, Balch WE, Kelly JW. Sawkar AR, et al. Among authors: wong ch. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15428-33. doi: 10.1073/pnas.192582899. Epub 2002 Nov 14. Proc Natl Acad Sci U S A. 2002. PMID: 12434014 Free PMC article.

3

Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening.

Best MD, Brik A, Chapman E, Lee LV, Cheng WC, Wong CH. Best MD, et al. Among authors: wong ch. Chembiochem. 2004 Jun 7;5(6):811-9. doi: 10.1002/cbic.200300841. Chembiochem. 2004. PMID: 15174164

4

Synthesis and high-throughput screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis.

Liu J, Numa MM, Liu H, Huang SJ, Sears P, Shikhman AR, Wong CH. Liu J, et al. Among authors: wong ch. J Org Chem. 2004 Sep 17;69(19):6273-83. doi: 10.1021/jo049355h. J Org Chem. 2004. PMID: 15357586

5

Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase.

Chang CF, Ho CW, Wu CY, Chao TA, Wong CH, Lin CH. Chang CF, et al. Among authors: wong ch. Chem Biol. 2004 Sep;11(9):1301-6. doi: 10.1016/j.chembiol.2004.07.009. Chem Biol. 2004. PMID: 15380190

6

Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles.

Sawkar AR, Adamski-Werner SL, Cheng WC, Wong CH, Beutler E, Zimmer KP, Kelly JW. Sawkar AR, et al. Among authors: wong ch. Chem Biol. 2005 Nov;12(11):1235-44. doi: 10.1016/j.chembiol.2005.09.007. Chem Biol. 2005. PMID: 16298303

7

Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.

Liang PH, Cheng WC, Lee YL, Yu HP, Wu YT, Lin YL, Wong CH. Liang PH, et al. Among authors: wong ch. Chembiochem. 2006 Jan;7(1):165-73. doi: 10.1002/cbic.200500321. Chembiochem. 2006. PMID: 16397876 Free PMC article.

8

Microtiter plate based chemistry and in situ screening: a useful approach for rapid inhibitor discovery.

Brik A, Wu CY, Wong CH. Brik A, et al. Among authors: wong ch. Org Biomol Chem. 2006 Apr 21;4(8):1446-57. doi: 10.1039/b600055j. Epub 2006 Mar 22. Org Biomol Chem. 2006. PMID: 16604207 Review.

9

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

Sanna MG, Wang SK, Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH, Rosen H. Sanna MG, et al. Among authors: wong ch. Nat Chem Biol. 2006 Aug;2(8):434-41. doi: 10.1038/nchembio804. Epub 2006 Jul 9. Nat Chem Biol. 2006. PMID: 16829954

10

Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics.

Cheng TJ, Sung MT, Liao HY, Chang YF, Chen CW, Huang CY, Chou LY, Wu YD, Chen YH, Cheng YS, Wong CH, Ma C, Cheng WC. Cheng TJ, et al. Among authors: wong ch. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):431-6. doi: 10.1073/pnas.0710868105. Epub 2008 Jan 8. Proc Natl Acad Sci U S A. 2008. PMID: 18182485 Free PMC article.

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