Nagase H - Search Results

1

Investigation of Beckett-Casy model 2: synthesis of novel 15-16 nornaltrexone derivatives and their pharmacology.

Nagase H, Imaide S, Tomatsu M, Nemoto T, Nakajima M, Nakao K, Mochizuki H, Fujii H. Nagase H, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3726-9. doi: 10.1016/j.bmcl.2010.04.080. Epub 2010 Apr 22. Bioorg Med Chem Lett. 2010. PMID: 20483601

2

Role of the spacer in conferring kappa opioid receptor selectivity to bivalent ligands related to norbinaltorphimine.

Portoghese PS, Garzon-Aburbeh A, Nagase H, Lin CE, Takemori AE. Portoghese PS, et al. Among authors: nagase h. J Med Chem. 1991 Apr;34(4):1292-6. doi: 10.1021/jm00108a008. J Med Chem. 1991. PMID: 1849995

3

Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole.

Portoghese PS, Nagase H, MaloneyHuss KE, Lin CE, Takemori AE. Portoghese PS, et al. Among authors: nagase h. J Med Chem. 1991 May;34(5):1715-20. doi: 10.1021/jm00109a027. J Med Chem. 1991. PMID: 1851846

4

Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.

Portoghese PS, Nagase H, Lipkowski AW, Larson DL, Takemori AE. Portoghese PS, et al. Among authors: nagase h. J Med Chem. 1988 Apr;31(4):836-41. doi: 10.1021/jm00399a026. J Med Chem. 1988. PMID: 2832604

5

The pharmacological profile of delta opioid receptor ligands, (+) and (-) TAN-67 on pain modulation.

Nagase H, Yajima Y, Fujii H, Kawamura K, Narita M, Kamei J, Suzuki T. Nagase H, et al. Life Sci. 2001 Apr 6;68(19-20):2227-31. doi: 10.1016/s0024-3205(01)01010-4. Life Sci. 2001. PMID: 11358331 Review.

6

Synthesis of optically active TAN-67, a highly selective delta opioid receptor agonist, and investigation of its pharmacological properties.

Fujii H, Kawai K, Kawamura K, Mizusuna A, Onoda Y, Murachi M, Tanaka T, Endoh T, Nagase H. Fujii H, et al. Among authors: nagase h. Drug Des Discov. 2001;17(4):325-30. Drug Des Discov. 2001. PMID: 11765135

7

Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system.

Umeuchi H, Togashi Y, Honda T, Nakao K, Okano K, Tanaka T, Nagase H. Umeuchi H, et al. Among authors: nagase h. Eur J Pharmacol. 2003 Sep 5;477(1):29-35. doi: 10.1016/j.ejphar.2003.08.007. Eur J Pharmacol. 2003. PMID: 14512095

8

Suppression of acute herpetic pain-related responses by the kappa-opioid receptor agonist (-)-17-cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-beta-[n-methyl-3-trans-3-(3-furyl) acrylamido] morphinan hydrochloride (TRK-820) in mice.

Takasaki I, Suzuki T, Sasaki A, Nakao K, Hirakata M, Okano K, Tanaka T, Nagase H, Shiraki K, Nojima H, Kuraishi Y. Takasaki I, et al. Among authors: nagase h. J Pharmacol Exp Ther. 2004 Apr;309(1):36-41. doi: 10.1124/jpet.103.059816. Epub 2004 Jan 7. J Pharmacol Exp Ther. 2004. PMID: 14711930

9

The first example of the stereoselective synthesis of 7 beta-carbamoyl-4,5alpha-epoxymorphinan via a novel and reactive gamma-lactone.

Fujii H, Hirano N, Uchiro H, Kawamura K, Nagase H. Fujii H, et al. Among authors: nagase h. Chem Pharm Bull (Tokyo). 2004 Jun;52(6):747-50. doi: 10.1248/cpb.52.747. Chem Pharm Bull (Tokyo). 2004. PMID: 15187399 Free article.

10

Drug design and synthesis of epsilon opioid receptor agonist: 17-(cyclopropylmethyl)-4,5alpha-epoxy-3,6beta-dihydroxy-6,14-endoethenomorphinan-7alpha-(N-methyl-N-phenethyl)carboxamide (TAN-821) inducing antinociception mediated by putative epsilon opioid receptor.

Fujii H, Narita M, Mizoguchi H, Murachi M, Tanaka T, Kawai K, Tseng LF, Nagase H. Fujii H, et al. Among authors: nagase h. Bioorg Med Chem. 2004 Aug 1;12(15):4133-45. doi: 10.1016/j.bmc.2004.05.024. Bioorg Med Chem. 2004. PMID: 15246090

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