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Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques.
Sui Y, Zhu Q, Gagnon S, Dzutsev A, Terabe M, Vaccari M, Venzon D, Klinman D, Strober W, Kelsall B, Franchini G, Belyakov IM, Berzofsky JA. Sui Y, et al. Among authors: klinman d. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9843-8. doi: 10.1073/pnas.0911932107. Epub 2010 May 10. Proc Natl Acad Sci U S A. 2010. PMID: 20457926 Free PMC article.
TLR agonists and/or IL-15 adjuvanted mucosal SIV vaccine reduced gut CD4⁺ memory T cell loss in SIVmac251-challenged rhesus macaques.
Sui Y, Gagnon S, Dzutsev A, Zhu Q, Yu H, Hogg A, Wang Y, Xia Z, Belyakov IM, Venzon D, Klinman D, Strober W, Kelsall B, Franchini G, Berzofsky JA. Sui Y, et al. Among authors: klinman d. Vaccine. 2011 Dec 9;30(1):59-68. doi: 10.1016/j.vaccine.2011.10.043. Epub 2011 Oct 29. Vaccine. 2011. PMID: 22041305 Free PMC article.
Vaccine-induced myeloid cell population dampens protective immunity to SIV.
Sui Y, Hogg A, Wang Y, Frey B, Yu H, Xia Z, Venzon D, McKinnon K, Smedley J, Gathuka M, Klinman D, Keele BF, Langermann S, Liu L, Franchini G, Berzofsky JA. Sui Y, et al. Among authors: klinman d. J Clin Invest. 2014 Jun;124(6):2538-49. doi: 10.1172/JCI73518. Epub 2014 May 16. J Clin Invest. 2014. PMID: 24837435 Free PMC article.
Mucosal vaccine efficacy against intrarectal SHIV is independent of anti-Env antibody response.
Sui Y, Lewis GK, Wang Y, Berckmueller K, Frey B, Dzutsev A, Vargas-Inchaustegui D, Mohanram V, Musich T, Shen X, DeVico A, Fouts T, Venzon D, Kirk J, Waters RC, Talton J, Klinman D, Clements J, Tomaras GD, Franchini G, Robert-Guroff M, Trinchieri G, Gallo RC, Berzofsky JA. Sui Y, et al. Among authors: klinman d. J Clin Invest. 2019 Mar 1;129(3):1314-1328. doi: 10.1172/JCI122110. Epub 2019 Feb 18. J Clin Invest. 2019. PMID: 30776026 Free PMC article.
322 results