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A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.
Bramsen JB, Pakula MM, Hansen TB, Bus C, Langkjær N, Odadzic D, Smicius R, Wengel SL, Chattopadhyaya J, Engels JW, Herdewijn P, Wengel J, Kjems J. Bramsen JB, et al. Among authors: engels jw. Nucleic Acids Res. 2010 Sep;38(17):5761-73. doi: 10.1093/nar/gkq341. Epub 2010 May 7. Nucleic Acids Res. 2010. PMID: 20453030 Free PMC article.
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.
Bramsen JB, Laursen MB, Nielsen AF, Hansen TB, Bus C, Langkjaer N, Babu BR, Højland T, Abramov M, Van Aerschot A, Odadzic D, Smicius R, Haas J, Andree C, Barman J, Wenska M, Srivastava P, Zhou C, Honcharenko D, Hess S, Müller E, Bobkov GV, Mikhailov SN, Fava E, Meyer TF, Chattopadhyaya J, Zerial M, Engels JW, Herdewijn P, Wengel J, Kjems J. Bramsen JB, et al. Among authors: engels jw. Nucleic Acids Res. 2009 May;37(9):2867-81. doi: 10.1093/nar/gkp106. Epub 2009 Mar 12. Nucleic Acids Res. 2009. PMID: 19282453 Free PMC article.
Chemical synthesis of 2'-O-alkylated siRNAs.
Engels JW, Odadzic D, Smicius R, Haas J. Engels JW, et al. Methods Mol Biol. 2010;623:155-70. doi: 10.1007/978-1-60761-588-0_10. Methods Mol Biol. 2010. PMID: 20217550
Gene silencing by chemically modified siRNAs.
Engels JW. Engels JW. N Biotechnol. 2013 Mar 25;30(3):302-7. doi: 10.1016/j.nbt.2012.07.002. Epub 2012 Jul 20. N Biotechnol. 2013. PMID: 22820489 Review.
Base-specific spin-labeling of RNA for structure determination.
Piton N, Mu Y, Stock G, Prisner TF, Schiemann O, Engels JW. Piton N, et al. Among authors: engels jw. Nucleic Acids Res. 2007;35(9):3128-43. doi: 10.1093/nar/gkm169. Epub 2007 Apr 22. Nucleic Acids Res. 2007. PMID: 17452362 Free PMC article.
147 results