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Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits.
Curtain CC, Ali F, Volitakis I, Cherny RA, Norton RS, Beyreuther K, Barrow CJ, Masters CL, Bush AI, Barnham KJ. Curtain CC, et al. Among authors: barnham kj. J Biol Chem. 2001 Jun 8;276(23):20466-73. doi: 10.1074/jbc.M100175200. Epub 2001 Mar 27. J Biol Chem. 2001. PMID: 11274207 Free article.
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, Zheng H, Tanzi RE, Masters CL, Bush AI. Cherny RA, et al. Among authors: barnham kj. Neuron. 2001 Jun;30(3):665-76. doi: 10.1016/s0896-6273(01)00317-8. Neuron. 2001. PMID: 11430801 Free article.
Cu2+-induced modification of the kinetics of A beta(1-42) channels.
Bahadi R, Farrelly PV, Kenna BL, Curtain CC, Masters CL, Cappai R, Barnham KJ, Kourie JI. Bahadi R, et al. Among authors: barnham kj. Am J Physiol Cell Physiol. 2003 Oct;285(4):C873-80. doi: 10.1152/ajpcell.00147.2003. Epub 2003 Jun 18. Am J Physiol Cell Physiol. 2003. PMID: 12814914 Free article.
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.
Barnham KJ, Ciccotosto GD, Tickler AK, Ali FE, Smith DG, Williamson NA, Lam YH, Carrington D, Tew D, Kocak G, Volitakis I, Separovic F, Barrow CJ, Wade JD, Masters CL, Cherny RA, Curtain CC, Bush AI, Cappai R. Barnham KJ, et al. J Biol Chem. 2003 Oct 31;278(44):42959-65. doi: 10.1074/jbc.M305494200. Epub 2003 Aug 18. J Biol Chem. 2003. PMID: 12925530 Free article.
206 results