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DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation.
Hastak K, Paul RK, Agarwal MK, Thakur VS, Amin AR, Agrawal S, Sramkoski RM, Jacobberger JW, Jackson MW, Stark GR, Agarwal ML. Hastak K, et al. Among authors: agarwal ml, agarwal mk. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6314-9. doi: 10.1073/pnas.0802080105. Epub 2008 Apr 23. Proc Natl Acad Sci U S A. 2008. PMID: 18434539 Free PMC article.
Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53.
Karan G, Wang H, Chakrabarti A, Karan S, Liu Z, Xia Z, Gundluru M, Moreton S, Saunthararajah Y, Jackson MW, Agarwal MK, Wald DN. Karan G, et al. Among authors: agarwal mk. Mol Cancer Ther. 2016 Apr;15(4):574-582. doi: 10.1158/1535-7163.MCT-15-0467. Epub 2016 Feb 16. Mol Cancer Ther. 2016. PMID: 26883273 Free PMC article.
237 results