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PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice.
Weber J, de la Rosa J, Grove CS, Schick M, Rad L, Baranov O, Strong A, Pfaus A, Friedrich MJ, Engleitner T, Lersch R, Öllinger R, Grau M, Menendez IG, Martella M, Kohlhofer U, Banerjee R, Turchaninova MA, Scherger A, Hoffman GJ, Hess J, Kuhn LB, Ammon T, Kim J, Schneider G, Unger K, Zimber-Strobl U, Heikenwälder M, Schmidt-Supprian M, Yang F, Saur D, Liu P, Steiger K, Chudakov DM, Lenz G, Quintanilla-Martinez L, Keller U, Vassiliou GS, Cadiñanos J, Bradley A, Rad R. Weber J, et al. Nat Commun. 2019 Mar 29;10(1):1415. doi: 10.1038/s41467-019-09180-3. Nat Commun. 2019. PMID: 30926791 Free PMC article.
Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia.
Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny-Geier G, Klein-Hitpass L, Williamson JC, Lehner PJ, Dürig J, Möllmann M, Rásó-Barnett L, Hughes K, Santoro A, Méndez-Ferrer S, Oostendorp RAJ, Zimber-Strobl U, Peschel C, Hodson DJ, Schmidt-Supprian M, Ringshausen I. Mangolini M, et al. Nat Commun. 2018 Sep 21;9(1):3839. doi: 10.1038/s41467-018-06069-5. Nat Commun. 2018. PMID: 30242258 Free PMC article.
The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.
Dutta S, Krause A, Vosberg S, Herold T, Ksienzyk B, Quintanilla-Martinez L, Tizazu B, Chopra M, Graf A, Krebs S, Blum H, Greif PA, Vetter A, Metzeler K, Rothenberg-Thurley M, Schneider MR, Dahlhoff M, Spiekermann K, Zimber-Strobl U, Wolf E, Bohlander SK. Dutta S, et al. Leukemia. 2016 May;30(5):1166-76. doi: 10.1038/leu.2015.349. Epub 2015 Dec 21. Leukemia. 2016. PMID: 26686248
Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.
Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP. Gamrekelashvili J, et al. Nat Commun. 2016 Aug 31;7:12597. doi: 10.1038/ncomms12597. Nat Commun. 2016. PMID: 27576369 Free PMC article.
Chronic CD30 signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells.
Sperling S, Fiedler P, Lechner M, Pollithy A, Ehrenberg S, Schiefer AI, Kenner L, Feuchtinger A, Kühn R, Swinerd G, Schmidt-Supprian M, Strobl LJ, Zimber-Strobl U. Sperling S, et al. Among authors: zimber strobl u. Blood. 2019 Jun 13;133(24):2597-2609. doi: 10.1182/blood.2018880138. Epub 2019 Apr 8. Blood. 2019. PMID: 30962205 Free article.
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