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A key role for lipoic acid synthesis during Plasmodium liver stage development.
Falkard B, Kumar TR, Hecht LS, Matthews KA, Henrich PP, Gulati S, Lewis RE, Manary MJ, Winzeler EA, Sinnis P, Prigge ST, Heussler V, Deschermeier C, Fidock D. Falkard B, et al. Among authors: henrich pp. Cell Microbiol. 2013 Sep;15(9):1585-604. doi: 10.1111/cmi.12137. Epub 2013 Apr 5. Cell Microbiol. 2013. PMID: 23490300 Free PMC article.
Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter.
Petersen I, Gabryszewski SJ, Johnston GL, Dhingra SK, Ecker A, Lewis RE, de Almeida MJ, Straimer J, Henrich PP, Palatulan E, Johnson DJ, Coburn-Flynn O, Sanchez C, Lehane AM, Lanzer M, Fidock DA. Petersen I, et al. Among authors: henrich pp. Mol Microbiol. 2015 Jul;97(2):381-95. doi: 10.1111/mmi.13035. Epub 2015 May 20. Mol Microbiol. 2015. PMID: 25898991 Free PMC article.
Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes.
Biddau M, Santha Kumar TR, Henrich P, Laine LM, Blackburn GJ, Chokkathukalam A, Li T, Lee Sim K, King L, Hoffman SL, Barrett MP, Coombs GH, McFadden GI, Fidock DA, Müller S, Sheiner L. Biddau M, et al. Int J Parasitol. 2021 May;51(6):441-453. doi: 10.1016/j.ijpara.2020.10.011. Epub 2021 Mar 11. Int J Parasitol. 2021. PMID: 33713652 Free PMC article.
Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.
Vanaerschot M, Lucantoni L, Li T, Combrinck JM, Ruecker A, Kumar TRS, Rubiano K, Ferreira PE, Siciliano G, Gulati S, Henrich PP, Ng CL, Murithi JM, Corey VC, Duffy S, Lieberman OJ, Veiga MI, Sinden RE, Alano P, Delves MJ, Lee Sim K, Winzeler EA, Egan TJ, Hoffman SL, Avery VM, Fidock DA. Vanaerschot M, et al. Among authors: henrich pp. Nat Microbiol. 2017 Oct;2(10):1403-1414. doi: 10.1038/s41564-017-0007-4. Epub 2017 Aug 14. Nat Microbiol. 2017. PMID: 28808258 Free PMC article.
Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum.
Hrycyna CA, Summers RL, Lehane AM, Pires MM, Namanja H, Bohn K, Kuriakose J, Ferdig M, Henrich PP, Fidock DA, Kirk K, Chmielewski J, Martin RE. Hrycyna CA, et al. Among authors: henrich pp. ACS Chem Biol. 2014 Mar 21;9(3):722-30. doi: 10.1021/cb4008953. Epub 2014 Jan 6. ACS Chem Biol. 2014. PMID: 24369685 Free PMC article.
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