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Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines.
Parmenopoulou V, Kantsadi AL, Tsirkone VG, Chatzileontiadou DS, Manta S, Zographos SE, Molfeta C, Archontis G, Agius L, Hayes JM, Leonidas DD, Komiotis D. Parmenopoulou V, et al. Among authors: komiotis d. Bioorg Med Chem. 2014 Sep 1;22(17):4810-25. doi: 10.1016/j.bmc.2014.06.058. Epub 2014 Jul 16. Bioorg Med Chem. 2014. PMID: 25092521
Glycogen phosphorylase as a target for type 2 diabetes: synthetic, biochemical, structural and computational evaluation of novel N-acyl-N´-(β-D-glucopyranosyl) urea inhibitors.
Kantsadi AL, Parmenopoulou V, Bakalov DN, Snelgrove L, Stravodimos GA, Chatzileontiadou DS, Manta S, Panagiotopoulou A, Hayes JM, Komiotis D, Leonidas DD. Kantsadi AL, et al. Among authors: komiotis d. Curr Top Med Chem. 2015;15(23):2373-89. doi: 10.2174/1568026615666150619142253. Curr Top Med Chem. 2015. PMID: 26088352
3'-axial CH2 OH substitution on glucopyranose does not increase glycogen phosphorylase inhibitory potency. QM/MM-PBSA calculations suggest why.
Manta S, Xipnitou A, Kiritsis C, Kantsadi AL, Hayes JM, Skamnaki VT, Lamprakis C, Kontou M, Zoumpoulakis P, Zographos SE, Leonidas DD, Komiotis D. Manta S, et al. Among authors: komiotis d. Chem Biol Drug Des. 2012 May;79(5):663-73. doi: 10.1111/j.1747-0285.2012.01349.x. Epub 2012 Mar 7. Chem Biol Drug Des. 2012. PMID: 22296957
Dideoxy fluoro-ketopyranosyl nucleosides as potent antiviral agents: synthesis and biological evaluation of 2,3- and 3,4-dideoxy-3-fluoro-4- and -2-keto-beta-d-glucopyranosyl derivatives of N(4)-benzoyl cytosine.
Manta S, Tsoukala E, Tzioumaki N, Goropevsek A, Pamulapati RT, Cencic A, Balzarini J, Komiotis D. Manta S, et al. Among authors: komiotis d. Eur J Med Chem. 2009 Jun;44(6):2696-704. doi: 10.1016/j.ejmech.2009.01.020. Epub 2009 Jan 29. Eur J Med Chem. 2009. PMID: 19246130 Free PMC article.
Unsaturated dideoxy fluoro-ketopyranosyl nucleosides as new cytostatic agents: a convenient synthesis of 2,6-dideoxy-3-fluoro-4-keto-beta-D-glucopyranosyl analogues of uracil, 5-fluorouracil, thymine, N4-benzoyl cytosine and N6-benzoyl adenine.
Manta S, Tzioumaki N, Tsoukala E, Panagiotopoulou A, Pelecanou M, Balzarini J, Komiotis D. Manta S, et al. Among authors: komiotis d. Eur J Med Chem. 2009 Nov;44(11):4764-71. doi: 10.1016/j.ejmech.2009.06.013. Epub 2009 Jun 18. Eur J Med Chem. 2009. PMID: 19595489
63 results