Fitzgerald KA - Search Results

1

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.

Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E. Duewell P, et al. Among authors: fitzgerald ka. Nature. 2010 Apr 29;464(7293):1357-61. doi: 10.1038/nature08938. Nature. 2010. PMID: 20428172 Free PMC article.

2

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.

Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T. Fitzgerald KA, et al. Nat Immunol. 2003 May;4(5):491-6. doi: 10.1038/ni921. Nat Immunol. 2003. PMID: 12692549

3

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.

Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT. Fitzgerald KA, et al. J Exp Med. 2003 Oct 6;198(7):1043-55. doi: 10.1084/jem.20031023. Epub 2003 Sep 29. J Exp Med. 2003. PMID: 14517278 Free PMC article.

4

TLR9 signals after translocating from the ER to CpG DNA in the lysosome.

Latz E, Schoenemeyer A, Visintin A, Fitzgerald KA, Monks BG, Knetter CF, Lien E, Nilsen NJ, Espevik T, Golenbock DT. Latz E, et al. Among authors: fitzgerald ka. Nat Immunol. 2004 Feb;5(2):190-8. doi: 10.1038/ni1028. Epub 2004 Jan 11. Nat Immunol. 2004. PMID: 14716310

5

The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.

Schoenemeyer A, Barnes BJ, Mancl ME, Latz E, Goutagny N, Pitha PM, Fitzgerald KA, Golenbock DT. Schoenemeyer A, et al. Among authors: fitzgerald ka. J Biol Chem. 2005 Apr 29;280(17):17005-12. doi: 10.1074/jbc.M412584200. Epub 2005 Jan 28. J Biol Chem. 2005. PMID: 15695821 Free article.

6

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.

Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT. Rowe DC, et al. Among authors: fitzgerald ka. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6299-304. doi: 10.1073/pnas.0510041103. Epub 2006 Apr 7. Proc Natl Acad Sci U S A. 2006. PMID: 16603631 Free PMC article.

7

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.

Tian J, Avalos AM, Mao SY, Chen B, Senthil K, Wu H, Parroche P, Drabic S, Golenbock D, Sirois C, Hua J, An LL, Audoly L, La Rosa G, Bierhaus A, Naworth P, Marshak-Rothstein A, Crow MK, Fitzgerald KA, Latz E, Kiener PA, Coyle AJ. Tian J, et al. Among authors: fitzgerald ka. Nat Immunol. 2007 May;8(5):487-96. doi: 10.1038/ni1457. Epub 2007 Apr 8. Nat Immunol. 2007. PMID: 17417641

8

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.

Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT. Halle A, et al. Among authors: fitzgerald ka. Nat Immunol. 2008 Aug;9(8):857-65. doi: 10.1038/ni.1636. Epub 2008 Jul 11. Nat Immunol. 2008. PMID: 18604209 Free PMC article.

9

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.

Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. Hornung V, et al. Among authors: fitzgerald ka. Nat Immunol. 2008 Aug;9(8):847-56. doi: 10.1038/ni.1631. Epub 2008 Jul 11. Nat Immunol. 2008. PMID: 18604214 Free PMC article.

10

TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.

Charrel-Dennis M, Latz E, Halmen KA, Trieu-Cuot P, Fitzgerald KA, Kasper DL, Golenbock DT. Charrel-Dennis M, et al. Among authors: fitzgerald ka. Cell Host Microbe. 2008 Dec 11;4(6):543-54. doi: 10.1016/j.chom.2008.11.002. Cell Host Microbe. 2008. PMID: 19064255 Free PMC article.

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