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Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III.
Shen Y, Boivin R, Yoneda N, Du H, Schiller S, Matsushima T, Goto M, Shirota H, Gusovsky F, Lemelin C, Jiang Y, Zhang Z, Pelletier R, Ikemori-Kawada M, Kawakami Y, Inoue A, Schnaderbeck M, Wang Y. Shen Y, et al. Bioorg Med Chem Lett. 2010 May 15;20(10):3155-7. doi: 10.1016/j.bmcl.2010.03.087. Epub 2010 Mar 30. Bioorg Med Chem Lett. 2010. PMID: 20399648
Macrocyclic ketone analogues of halichondrin B.
Zheng W, Seletsky BM, Palme MH, Lydon PJ, Singer LA, Chase CE, Lemelin CA, Shen Y, Davis H, Tremblay L, Towle MJ, Salvato KA, Wels BF, Aalfs KK, Kishi Y, Littlefield BA, Yu MJ. Zheng W, et al. Among authors: shen y. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5551-4. doi: 10.1016/j.bmcl.2004.08.069. Bioorg Med Chem Lett. 2004. PMID: 15482922
Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo.
Lamphier M, Zheng W, Latz E, Spyvee M, Hansen H, Rose J, Genest M, Yang H, Shaffer C, Zhao Y, Shen Y, Liu C, Liu D, Mempel TR, Rowbottom C, Chow J, Twine NC, Yu M, Gusovsky F, Ishizaka ST. Lamphier M, et al. Among authors: shen y. Mol Pharmacol. 2014 Mar;85(3):429-40. doi: 10.1124/mol.113.089821. Epub 2013 Dec 16. Mol Pharmacol. 2014. PMID: 24342772
Antiproliferative and antiplasmodial compounds from selected Streptomyces species.
Harinantenaina Rakotondraibe L, Rasolomampianina R, Park HY, Li J, Slebodnik C, Brodie PJ, Blasiak LC, Hill R, TenDyke K, Shen Y, Cassera MB, Rejo F, Kingston DG. Harinantenaina Rakotondraibe L, et al. Among authors: shen y. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5646-9. doi: 10.1016/j.bmcl.2015.07.103. Epub 2015 Aug 6. Bioorg Med Chem Lett. 2015. PMID: 26508548 Free PMC article.
Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking.
Bao X, Zheng W, Hata Sugi N, Agarwala KL, Xu Q, Wang Z, Tendyke K, Lee W, Parent L, Li W, Cheng H, Shen Y, Taylor N, Dezso Z, Du H, Kotake Y, Zhao N, Wang J, Postema M, Woodall-Jappe M, Takase Y, Uenaka T, Kingston DG, Nomoto K. Bao X, et al. Among authors: shen y. Cancer Biol Ther. 2015;16(4):589-601. doi: 10.1080/15384047.2015.1019184. Epub 2015 Mar 2. Cancer Biol Ther. 2015. PMID: 25729885 Free PMC article.
Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61.
Huang KC, Chen Z, Jiang Y, Akare S, Kolber-Simonds D, Condon K, Agoulnik S, Tendyke K, Shen Y, Wu KM, Mathieu S, Choi HW, Zhu X, Shimizu H, Kotake Y, Gerwick WH, Uenaka T, Woodall-Jappe M, Nomoto K. Huang KC, et al. Among authors: shen y. Mol Cancer Ther. 2016 Jun;15(6):1208-16. doi: 10.1158/1535-7163.MCT-15-0648. Epub 2016 Mar 29. Mol Cancer Ther. 2016. PMID: 27196783
Antiproliferative homoscalarane sesterterpenes from two Madagascan sponges.
Harinantenaina L, Brodie PJ, Maharavo J, Bakary G, TenDyke K, Shen Y, Kingston DG. Harinantenaina L, et al. Among authors: shen y. Bioorg Med Chem. 2013 Jun 1;21(11):2912-7. doi: 10.1016/j.bmc.2013.03.078. Epub 2013 Apr 6. Bioorg Med Chem. 2013. PMID: 23623678 Free PMC article.
Cardenolides of Leptadenia madagascariensis from the Madagascar dry forest.
Pan E, Harinantenaina L, Brodie PJ, Callmander M, Rakotonandrasana S, Rakotobe E, Rasamison VE, Tendyke K, Shen Y, Suh EM, Kingston DG. Pan E, et al. Among authors: shen y. Bioorg Med Chem. 2011 Jan 1;19(1):422-8. doi: 10.1016/j.bmc.2010.11.021. Epub 2010 Nov 11. Bioorg Med Chem. 2011. PMID: 21159516 Free PMC article.
Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest.
Liu Y, Young K, Rakotondraibe LH, Brodie PJ, Wiley JD, Cassera MB, Callmander MW, Rakotondrajaona R, Rakotobe E, Rasamison VE, TenDyke K, Shen Y, Kingston DG. Liu Y, et al. Among authors: shen y. J Nat Prod. 2015 Jul 24;78(7):1543-7. doi: 10.1021/np501020m. Epub 2015 Jun 19. J Nat Prod. 2015. PMID: 26091020 Free PMC article.
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