Luo J - Search Results

1

Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin.

Luo J, Li W, Zhao Y, Fu H, Ma DL, Tang J, Li C, Peoples RW, Li F, Wang Q, Huang P, Xia J, Pang Y, Han Y. Luo J, et al. J Biol Chem. 2010 Jun 25;285(26):19947-58. doi: 10.1074/jbc.M110.111286. Epub 2010 Apr 19. J Biol Chem. 2010. PMID: 20404346 Free PMC article.

2

Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors.

Li W, Pi R, Chan HH, Fu H, Lee NT, Tsang HW, Pu Y, Chang DC, Li C, Luo J, Xiong K, Li Z, Xue H, Carlier PR, Pang Y, Tsim KW, Li M, Han Y. Li W, et al. Among authors: luo j. J Biol Chem. 2005 May 6;280(18):18179-88. doi: 10.1074/jbc.M411085200. Epub 2005 Feb 14. J Biol Chem. 2005. PMID: 15710623 Free article.

3

Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase.

Li W, Xue J, Niu C, Fu H, Lam CS, Luo J, Chan HH, Xue H, Kan KK, Lee NT, Li C, Pang Y, Li M, Tsim KW, Jiang H, Chen K, Li X, Han Y. Li W, et al. Among authors: luo j. Mol Pharmacol. 2007 May;71(5):1258-67. doi: 10.1124/mol.106.029108. Epub 2007 Feb 13. Mol Pharmacol. 2007. PMID: 17299028

4

Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents.

Luo J, Li W, Liu Y, Zhang W, Fu H, Lee NT, Yu H, Pang Y, Huang P, Xia J, Li ZW, Li C, Han Y. Luo J, et al. Biochem Biophys Res Commun. 2007 Sep 21;361(2):505-9. doi: 10.1016/j.bbrc.2007.07.043. Epub 2007 Jul 20. Biochem Biophys Res Commun. 2007. PMID: 17655827

5

Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently.

Fu H, Dou J, Li W, Cui W, Mak S, Hu Q, Luo J, Lam CS, Pang Y, Youdim MB, Han Y. Fu H, et al. Among authors: luo j. Eur J Pharmacol. 2009 Nov 25;623(1-3):14-21. doi: 10.1016/j.ejphar.2009.09.013. Epub 2009 Sep 16. Eur J Pharmacol. 2009. PMID: 19765582

6

Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets.

Zhao Y, Dou J, Luo J, Li W, Chan HH, Cui W, Zhang H, Han R, Carlier PR, Zhang X, Han Y. Zhao Y, et al. Among authors: luo j. Brain Res. 2011 Nov 3;1421:100-9. doi: 10.1016/j.brainres.2011.09.014. Epub 2011 Sep 16. Brain Res. 2011. PMID: 21978549

7

Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels.

Fu H, Li W, Lao Y, Luo J, Lee NT, Kan KK, Tsang HW, Tsim KW, Pang Y, Li Z, Chang DC, Li M, Han Y. Fu H, et al. Among authors: luo j. J Neurochem. 2006 Sep;98(5):1400-10. doi: 10.1111/j.1471-4159.2006.03960.x. Epub 2006 Jun 12. J Neurochem. 2006. PMID: 16771827 Free article.

8

Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity.

Fu H, Li W, Luo J, Lee NT, Li M, Tsim KW, Pang Y, Youdim MB, Han Y. Fu H, et al. Among authors: luo j. Biochem Biophys Res Commun. 2008 Feb 15;366(3):631-6. doi: 10.1016/j.bbrc.2007.11.068. Epub 2007 Nov 26. Biochem Biophys Res Commun. 2008. PMID: 18039469

9

Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic-independent mechanisms.

Fu H, Dou J, Li W, Luo J, Li KC, Lam CS, Lee NT, Li M, Han Y. Fu H, et al. Among authors: luo j. Neuropharmacology. 2008 Mar;54(4):755-65. doi: 10.1016/j.neuropharm.2007.12.003. Epub 2007 Dec 23. Neuropharmacology. 2008. PMID: 18222492

10

Preventing H₂O₂-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone.

Cui W, Li W, Zhao Y, Mak S, Gao Y, Luo J, Zhang H, Liu Y, Carlier PR, Rong J, Han Y. Cui W, et al. Among authors: luo j. Brain Res. 2011 Jun 7;1394:14-23. doi: 10.1016/j.brainres.2011.02.006. Epub 2011 Feb 9. Brain Res. 2011. PMID: 21315693

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