Wells G - Search Results

1

Synthesis of antitumour (1H-1,2,3-triazol-4-yl)-4-hydroxycyclohexa-2,5-dien-1-ones by copper-catalysed Huisgen cycloadditions.

McCarroll AJ, Matthews CS, Wells G, Bradshaw TD, Stevens MF. McCarroll AJ, et al. Among authors: wells g. Org Biomol Chem. 2010 May 7;8(9):2078-84. doi: 10.1039/b920039h. Epub 2010 Mar 3. Org Biomol Chem. 2010. PMID: 20401384

2

4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.

Wells G, Berry JM, Bradshaw TD, Burger AM, Seaton A, Wang B, Westwell AD, Stevens MF. Wells G, et al. J Med Chem. 2003 Feb 13;46(4):532-41. doi: 10.1021/jm020984y. J Med Chem. 2003. PMID: 12570375

3

Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents.

Berry JM, Bradshaw TD, Fichtner I, Ren R, Schwalbe CH, Wells G, Chew EH, Stevens MF, Westwell AD. Berry JM, et al. Among authors: wells g. J Med Chem. 2005 Jan 27;48(2):639-44. doi: 10.1021/jm040859h. J Med Chem. 2005. PMID: 15658878

4

Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols').

Lion CJ, Matthews CS, Wells G, Bradshaw TD, Stevens MF, Westwell AD. Lion CJ, et al. Among authors: wells g. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5005-8. doi: 10.1016/j.bmcl.2006.07.072. Bioorg Med Chem Lett. 2006. PMID: 16908135

5

Elucidation of thioredoxin as a molecular target for antitumor quinols.

Bradshaw TD, Matthews CS, Cookson J, Chew EH, Shah M, Bailey K, Monks A, Harris E, Westwell AD, Wells G, Laughton CA, Stevens MF. Bradshaw TD, et al. Among authors: wells g. Cancer Res. 2005 May 1;65(9):3911-9. doi: 10.1158/0008-5472.CAN-04-4141. Cancer Res. 2005. PMID: 15867391

6

Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines.

Mortimer CG, Wells G, Crochard JP, Stone EL, Bradshaw TD, Stevens MF, Westwell AD. Mortimer CG, et al. Among authors: wells g. J Med Chem. 2006 Jan 12;49(1):179-85. doi: 10.1021/jm050942k. J Med Chem. 2006. PMID: 16392802

7

Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648).

Aiello S, Wells G, Stone EL, Kadri H, Bazzi R, Bell DR, Stevens MF, Matthews CS, Bradshaw TD, Westwell AD. Aiello S, et al. Among authors: wells g. J Med Chem. 2008 Aug 28;51(16):5135-9. doi: 10.1021/jm800418z. Epub 2008 Jul 31. J Med Chem. 2008. PMID: 18666770

8

Antitumour benzothiazoles. Part 10: the synthesis and antitumour activity of benzothiazole substituted quinol derivatives.

Wells G, Bradshaw TD, Diana P, Seaton A, Shi DF, Westwell AD, Stevens MF. Wells G, et al. Bioorg Med Chem Lett. 2000 Mar 6;10(5):513-5. doi: 10.1016/s0960-894x(00)00027-5. Bioorg Med Chem Lett. 2000. PMID: 10743960

9

Development of novel apoferritin formulations for antitumour benzothiazoles.

Breen AF, Wells G, Turyanska L, Bradshaw TD. Breen AF, et al. Among authors: wells g. Cancer Rep (Hoboken). 2019 Aug;2(4):e1155. doi: 10.1002/cnr2.1155. Epub 2019 Jan 16. Cancer Rep (Hoboken). 2019. PMID: 32721126 Free PMC article.

10

Structural studies on bioactive compounds. 32. Oxidation of tyrphostin protein tyrosine kinase inhibitors with hypervalent iodine reagents.

Wells G, Seaton A, Stevens MF. Wells G, et al. J Med Chem. 2000 Apr 20;43(8):1550-62. doi: 10.1021/jm990947f. J Med Chem. 2000. PMID: 10780912

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