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Discovery of an orally-active nonsteroidal androgen receptor pure antagonist and the structure-activity relationships of its derivatives.
Tachibana K, Imaoka I, Shiraishi T, Yoshino H, Nakamura M, Ohta M, Kawata H, Taniguchi K, Ishikura N, Tsunenari T, Saito H, Nagamuta M, Nakagawa T, Takanashi K, Onuma E, Sato H. Tachibana K, et al. Among authors: onuma e. Chem Pharm Bull (Tokyo). 2008 Nov;56(11):1555-61. doi: 10.1248/cpb.56.1555. Chem Pharm Bull (Tokyo). 2008. PMID: 18981605 Free article.
Discovery and structure-activity relationships of new steroidal compounds bearing a carboxy-terminal side chain as androgen receptor pure antagonists.
Tachibana K, Imaoka I, Yoshino H, Kato N, Nakamura M, Ohta M, Kawata H, Taniguchi K, Ishikura N, Nagamuta M, Onuma E, Sato H. Tachibana K, et al. Among authors: onuma e. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5573-6. doi: 10.1016/j.bmcl.2007.07.090. Epub 2007 Aug 22. Bioorg Med Chem Lett. 2007. PMID: 17804229
A novel nonsecosteroidal VDR agonist (CH5036249) exhibits efficacy in a spontaneous benign prostatic hyperplasia beagle model.
Taniguchi K, Katagiri K, Kashiwagi H, Harada S, Sugimoto Y, Shimizu Y, Arakawa H, Ito T, Yamazaki M, Watanabe T, Kato A, Hoshino E, Takahashi T, Esaki T, Suzuki M, Takeda S, Ichikawa F, Harada A, Sekiguchi N, Ishigai M, Kawata H, Yoneya T, Onuma E, Sudoh M, Aoki Y. Taniguchi K, et al. Among authors: onuma e. J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):204-7. doi: 10.1016/j.jsbmb.2010.03.043. Epub 2010 Mar 18. J Steroid Biochem Mol Biol. 2010. PMID: 20304062
57 results