Kurth MJ - Search Results

1

Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles.

Ye L, Knapp JM, Sangwung P, Fettinger JC, Verkman AS, Kurth MJ. Ye L, et al. Among authors: kurth mj. J Med Chem. 2010 May 13;53(9):3772-81. doi: 10.1021/jm100235h. J Med Chem. 2010. PMID: 20373765 Free PMC article.

2

The solid-phase Zincke reaction: preparation of omega-hydroxy pyridinium salts in the search for CFTR activation.

Eda M, Kurth MJ, Nantz MH. Eda M, et al. Among authors: kurth mj. J Org Chem. 2000 Aug 25;65(17):5131-5. doi: 10.1021/jo0001636. J Org Chem. 2000. PMID: 10993337

3

Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds.

Galietta LJ, Springsteel MF, Eda M, Niedzinski EJ, By K, Haddadin MJ, Kurth MJ, Nantz MH, Verkman AS. Galietta LJ, et al. Among authors: kurth mj. J Biol Chem. 2001 Jun 8;276(23):19723-8. doi: 10.1074/jbc.M101892200. Epub 2001 Mar 21. J Biol Chem. 2001. PMID: 11262417 Free article.

4

CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds.

Caci E, Folli C, Zegarra-Moran O, Ma T, Springsteel MF, Sammelson RE, Nantz MH, Kurth MJ, Verkman AS, Galietta LJ. Caci E, et al. Among authors: kurth mj. Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L180-8. doi: 10.1152/ajplung.00351.2002. Epub 2003 Mar 21. Am J Physiol Lung Cell Mol Physiol. 2003. PMID: 12651632 Free article.

5

3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators.

Sammelson RE, Ma T, Galietta LJ, Verkman AS, Kurth MJ. Sammelson RE, et al. Among authors: kurth mj. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2509-12. doi: 10.1016/s0960-894x(03)00482-7. Bioorg Med Chem Lett. 2003. PMID: 12852954

6

Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain.

Springsteel MF, Galietta LJ, Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth MJ, Nantz MH. Springsteel MF, et al. Among authors: kurth mj. Bioorg Med Chem. 2003 Sep 1;11(18):4113-20. doi: 10.1016/s0968-0896(03)00435-8. Bioorg Med Chem. 2003. PMID: 12927873

7

Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating.

Pedemonte N, Sonawane ND, Taddei A, Hu J, Zegarra-Moran O, Suen YF, Robins LI, Dicus CW, Willenbring D, Nantz MH, Kurth MJ, Galietta LJ, Verkman AS. Pedemonte N, et al. Among authors: kurth mj. Mol Pharmacol. 2005 May;67(5):1797-807. doi: 10.1124/mol.105.010959. Epub 2005 Feb 18. Mol Pharmacol. 2005. PMID: 15722457

8

Stannous chloride in alcohol: a one-pot conversion of 2-nitro-N-arylbenzamides to 2,3-dihydro-1H-quinazoline-4-ones.

Yoo CL, Fettinger JC, Kurth MJ. Yoo CL, et al. Among authors: kurth mj. J Org Chem. 2005 Aug 19;70(17):6941-3. doi: 10.1021/jo050450f. J Org Chem. 2005. PMID: 16095321

9

A novel route to fully substituted 1H-pyrazoles.

Suen YF, Hope H, Nantz MH, Haddadin MJ, Kurth MJ. Suen YF, et al. Among authors: kurth mj. J Org Chem. 2005 Oct 14;70(21):8468-71. doi: 10.1021/jo051319a. J Org Chem. 2005. PMID: 16209593

10

Sulfamoyl-4-oxoquinoline-3-carboxamides: novel potentiators of defective DeltaF508-cystic fibrosis transmembrane conductance regulator chloride channel gating.

Suen YF, Robins L, Yang B, Verkman AS, Nantz MH, Kurth MJ. Suen YF, et al. Among authors: kurth mj. Bioorg Med Chem Lett. 2006 Feb;16(3):537-40. doi: 10.1016/j.bmcl.2005.10.050. Epub 2005 Nov 8. Bioorg Med Chem Lett. 2006. PMID: 16288863

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