Toney MD - Search Results

1

Targeting multiple chorismate-utilizing enzymes with a single inhibitor: validation of a three-stage design.

Ziebart KT, Dixon SM, Avila B, El-Badri MH, Guggenheim KG, Kurth MJ, Toney MD. Ziebart KT, et al. Among authors: toney md. J Med Chem. 2010 May 13;53(9):3718-29. doi: 10.1021/jm100158v. J Med Chem. 2010. PMID: 20359225

2

Aminodeoxychorismate synthase inhibitors from one-bead one-compound combinatorial libraries: "staged" inhibitor design.

Dixon S, Ziebart KT, He Z, Jeddeloh M, Yoo CL, Wang X, Lehman A, Lam KS, Toney MD, Kurth MJ. Dixon S, et al. Among authors: toney md. J Med Chem. 2006 Dec 14;49(25):7413-26. doi: 10.1021/jm0609869. J Med Chem. 2006. PMID: 17149871

3

Nucleophile specificity in anthranilate synthase, aminodeoxychorismate synthase, isochorismate synthase, and salicylate synthase.

Ziebart KT, Toney MD. Ziebart KT, et al. Among authors: toney md. Biochemistry. 2010 Apr 6;49(13):2851-9. doi: 10.1021/bi100021x. Biochemistry. 2010. PMID: 20170126

4

Orthogonally protected thiazole and isoxazole diamino acids: an efficient synthetic route.

Butler JD, Coffman KC, Ziebart KT, Toney MD, Kurth MJ. Butler JD, et al. Among authors: toney md. Chemistry. 2010 Aug 9;16(30):9002-5. doi: 10.1002/chem.201001492. Chemistry. 2010. PMID: 20623732 No abstract available.

5

Conversion of aminodeoxychorismate synthase into anthranilate synthase with Janus mutations: mechanism of pyruvate elimination catalyzed by chorismate enzymes.

Culbertson JE, Chung Dh, Ziebart KT, Espiritu E, Toney MD. Culbertson JE, et al. Among authors: toney md. Biochemistry. 2015 Apr 14;54(14):2372-84. doi: 10.1021/acs.biochem.5b00013. Epub 2015 Apr 2. Biochemistry. 2015. PMID: 25710100

6

Slow-binding human serine racemase inhibitors from high-throughput screening of combinatorial libraries.

Dixon SM, Li P, Liu R, Wolosker H, Lam KS, Kurth MJ, Toney MD. Dixon SM, et al. Among authors: toney md. J Med Chem. 2006 Apr 20;49(8):2388-97. doi: 10.1021/jm050701c. J Med Chem. 2006. PMID: 16610782

7

Conservation of mechanism in three chorismate-utilizing enzymes.

He Z, Stigers Lavoie KD, Bartlett PA, Toney MD. He Z, et al. Among authors: toney md. J Am Chem Soc. 2004 Mar 3;126(8):2378-85. doi: 10.1021/ja0389927. J Am Chem Soc. 2004. PMID: 14982443

8

Chemoenzymatic synthesis of 1-deaza-pyridoxal 5'-phosphate.

Griswold WR, Toney MD. Griswold WR, et al. Among authors: toney md. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1352-4. doi: 10.1016/j.bmcl.2010.01.002. Epub 2010 Jan 7. Bioorg Med Chem Lett. 2010. PMID: 20097067 Free PMC article.

9

Direct detection and kinetic analysis of covalent intermediate formation in the 4-amino-4-deoxychorismate synthase catalyzed reaction.

He Z, Toney MD. He Z, et al. Among authors: toney md. Biochemistry. 2006 Apr 18;45(15):5019-28. doi: 10.1021/bi052216p. Biochemistry. 2006. PMID: 16605270

10

Expression and characterization of PhzE from P. aeruginosa PAO1: aminodeoxyisochorismate synthase involved in pyocyanin and phenazine-1-carboxylate production.

Culbertson JE, Toney MD. Culbertson JE, et al. Among authors: toney md. Biochim Biophys Acta. 2013 Jan;1834(1):240-6. doi: 10.1016/j.bbapap.2012.10.010. Epub 2012 Oct 23. Biochim Biophys Acta. 2013. PMID: 23099261

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