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Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial.
Näntö-Salonen K, Kupila A, Simell S, Siljander H, Salonsaari T, Hekkala A, Korhonen S, Erkkola R, Sipilä JI, Haavisto L, Siltala M, Tuominen J, Hakalax J, Hyöty H, Ilonen J, Veijola R, Simell T, Knip M, Simell O. Näntö-Salonen K, et al. Among authors: simell t, simell s, simell o. Lancet. 2008 Nov 15;372(9651):1746-55. doi: 10.1016/S0140-6736(08)61309-4. Epub 2008 Sep 22. Lancet. 2008. PMID: 18814906 Clinical Trial.
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes.
Oresic M, Simell S, Sysi-Aho M, Näntö-Salonen K, Seppänen-Laakso T, Parikka V, Katajamaa M, Hekkala A, Mattila I, Keskinen P, Yetukuri L, Reinikainen A, Lähde J, Suortti T, Hakalax J, Simell T, Hyöty H, Veijola R, Ilonen J, Lahesmaa R, Knip M, Simell O. Oresic M, et al. Among authors: simell t, simell s, simell o. J Exp Med. 2008 Dec 22;205(13):2975-84. doi: 10.1084/jem.20081800. Epub 2008 Dec 15. J Exp Med. 2008. PMID: 19075291 Free PMC article.
Impact of intranasal insulin on insulin antibody affinity and isotypes in young children with HLA-conferred susceptibility to type 1 diabetes.
Ryhänen SJ, Härkönen T, Siljander H, Näntö-Salonen K, Simell T, Hyöty H, Ilonen J, Veijola R, Simell O, Knip M. Ryhänen SJ, et al. Among authors: simell t, simell o. Diabetes Care. 2011 Jun;34(6):1383-8. doi: 10.2337/dc10-1449. Epub 2011 Apr 22. Diabetes Care. 2011. PMID: 21515841 Free PMC article. Clinical Trial.
Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility.
Kallionpää H, Elo LL, Laajala E, Mykkänen J, Ricaño-Ponce I, Vaarma M, Laajala TD, Hyöty H, Ilonen J, Veijola R, Simell T, Wijmenga C, Knip M, Lähdesmäki H, Simell O, Lahesmaa R. Kallionpää H, et al. Among authors: simell t, simell o. Diabetes. 2014 Jul;63(7):2402-14. doi: 10.2337/db13-1775. Epub 2014 Feb 18. Diabetes. 2014. PMID: 24550192 Free article.
Serum proteomes distinguish children developing type 1 diabetes in a cohort with HLA-conferred susceptibility.
Moulder R, Bhosale SD, Erkkilä T, Laajala E, Salmi J, Nguyen EV, Kallionpää H, Mykkänen J, Vähä-Mäkilä M, Hyöty H, Veijola R, Ilonen J, Simell T, Toppari J, Knip M, Goodlett DR, Lähdesmäki H, Simell O, Lahesmaa R. Moulder R, et al. Among authors: simell t, simell o. Diabetes. 2015 Jun;64(6):2265-78. doi: 10.2337/db14-0983. Epub 2015 Jan 23. Diabetes. 2015. PMID: 25616278
Reduced β-cell function in early preclinical type 1 diabetes.
Koskinen MK, Helminen O, Matomäki J, Aspholm S, Mykkänen J, Mäkinen M, Simell V, Vähä-Mäkilä M, Simell T, Ilonen J, Knip M, Veijola R, Toppari J, Simell O. Koskinen MK, et al. Among authors: simell v, simell t, simell o. Eur J Endocrinol. 2016 Mar;174(3):251-9. doi: 10.1530/EJE-15-0674. Epub 2015 Nov 30. Eur J Endocrinol. 2016. PMID: 26620391 Free PMC article.
90 results