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Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.
Ruas M, Rietdorf K, Arredouani A, Davis LC, Lloyd-Evans E, Koegel H, Funnell TM, Morgan AJ, Ward JA, Watanabe K, Cheng X, Churchill GC, Zhu MX, Platt FM, Wessel GM, Parrington J, Galione A. Ruas M, et al. Among authors: cheng x. Curr Biol. 2010 Apr 27;20(8):703-9. doi: 10.1016/j.cub.2010.02.049. Epub 2010 Mar 25. Curr Biol. 2010. PMID: 20346675 Free PMC article.
NAADP mobilizes calcium from acidic organelles through two-pore channels.
Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX. Calcraft PJ, et al. Among authors: cheng x. Nature. 2009 May 28;459(7246):596-600. doi: 10.1038/nature08030. Epub 2009 Apr 22. Nature. 2009. PMID: 19387438 Free PMC article.
In vitro generation of mature human osteoclasts.
Hemingway F, Cheng X, Knowles HJ, Estrada FM, Gordon S, Athanasou NA. Hemingway F, et al. Among authors: cheng x. Calcif Tissue Int. 2011 Nov;89(5):389-95. doi: 10.1007/s00223-011-9530-0. Epub 2011 Sep 30. Calcif Tissue Int. 2011. PMID: 21960377
PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands.
Mishra V, Singh A, Korzinkin M, Cheng X, Wing C, Sarkisova V, Koppayi AL, Pogorelskaya A, Glushchenko O, Sundaresan M, Thodima V, Carter J, Ito K, Scherle P, Trzcinska A, Ozerov I, Vokes EE, Cole G, Pun FW, Shen L, Miao Y, Pearson AT, Lingen MW, Ruggeri B, Rosenberg AJ, Zhavoronkov A, Agrawal N, Izumchenko E. Mishra V, et al. Among authors: cheng x. J Exp Clin Cancer Res. 2025 Jan 11;44(1):11. doi: 10.1186/s13046-024-03270-x. J Exp Clin Cancer Res. 2025. PMID: 39794830
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