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A role for G(z) in pancreatic islet beta-cell biology.
Kimple ME, Nixon AB, Kelly P, Bailey CL, Young KH, Fields TA, Casey PJ. Kimple ME, et al. J Biol Chem. 2005 Sep 9;280(36):31708-13. doi: 10.1074/jbc.M506700200. Epub 2005 Jul 6. J Biol Chem. 2005. PMID: 16157560 Free article.
Agonist-independent Gαz activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes.
Schaid MD, Green CL, Peter DC, Gallagher SJ, Guthery E, Carbajal KA, Harrington JM, Kelly GM, Reuter A, Wehner ML, Brill AL, Neuman JC, Lamming DW, Kimple ME. Schaid MD, et al. Among authors: kimple me. J Biol Chem. 2021 Jan-Jun;296:100056. doi: 10.1074/jbc.RA120.015585. Epub 2020 Nov 24. J Biol Chem. 2021. PMID: 33172888 Free PMC article.
Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage.
Bosma KJ, Andrei SR, Katz LS, Smith AA, Dunn JC, Ricciardi VF, Ramirez MA, Baumel-Alterzon S, Pace WA, Carroll DT, Overway EM, Wolf EM, Kimple ME, Sheng Q, Scott DK, Breyer RM, Gannon M. Bosma KJ, et al. Among authors: kimple me. Mol Metab. 2021 Dec;54:101347. doi: 10.1016/j.molmet.2021.101347. Epub 2021 Oct 6. Mol Metab. 2021. PMID: 34626853 Free PMC article.
Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 β-cell line.
Krautkramer KA, Linnemann AK, Fontaine DA, Whillock AL, Harris TW, Schleis GJ, Truchan NA, Marty-Santos L, Lavine JA, Cleaver O, Kimple ME, Davis DB. Krautkramer KA, et al. Among authors: kimple me. Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E600-10. doi: 10.1152/ajpendo.00147.2013. Epub 2013 Jul 16. Am J Physiol Endocrinol Metab. 2013. PMID: 23860123 Free PMC article.
57 results