Wang EQ - Search Results

1

Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence.

Rollema H, Shrikhande A, Ward KM, Tingley FD 3rd, Coe JW, O'Neill BT, Tseng E, Wang EQ, Mather RJ, Hurst RS, Williams KE, de Vries M, Cremers T, Bertrand S, Bertrand D. Rollema H, et al. Among authors: wang eq. Br J Pharmacol. 2010 May;160(2):334-45. doi: 10.1111/j.1476-5381.2010.00682.x. Epub 2010 Mar 22. Br J Pharmacol. 2010. PMID: 20331614 Free PMC article.

2

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model.

Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E, Chen C, Chen X, Choo E, Cianfrogna J, Cox LM, Gibbs JP, Gibbs MA, Hatch H, Hop CE, Kasman IN, Laperle J, Liu J, Liu X, Logman M, Maclin D, Nedza FM, Nelson F, Olson E, Rahematpura S, Raunig D, Rogers S, Schmidt K, Spracklin DK, Szewc M, Troutman M, Tseng E, Tu M, Van Deusen JW, Venkatakrishnan K, Walens G, Wang EQ, Wong D, Yasgar AS, Zhang C. Doran A, et al. Among authors: wang eq. Drug Metab Dispos. 2005 Jan;33(1):165-74. doi: 10.1124/dmd.104.001230. Epub 2004 Oct 22. Drug Metab Dispos. 2005. PMID: 15502009

3

Improved preclinical cardiovascular therapeutic indices with long-term inhibition of norepinephrine reuptake using reboxetine.

Fossa AA, Wisialowski TA, Cremers T, van der Hart M, Tseng E, Deng S, Rollema H, Wang EQ. Fossa AA, et al. Among authors: wang eq. Toxicol Appl Pharmacol. 2012 Nov 1;264(3):343-50. doi: 10.1016/j.taap.2012.09.010. Epub 2012 Sep 19. Toxicol Appl Pharmacol. 2012. PMID: 23000177

4

Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.

Fossa AA, Wisialowski T, Wolfgang E, Wang E, Avery M, Raunig DL, Fermini B. Fossa AA, et al. Eur J Pharmacol. 2004 Feb 20;486(2):209-21. doi: 10.1016/j.ejphar.2003.12.028. Eur J Pharmacol. 2004. PMID: 14975710

5

Effects of Renal Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.

Wang EQ, Le V, Winton JA, Tripathy S, Raje S, Wang L, Dowty ME, Malhotra BK. Wang EQ, et al. Among authors: wang l. J Clin Pharmacol. 2022 Apr;62(4):505-519. doi: 10.1002/jcph.1980. Epub 2022 Feb 15. J Clin Pharmacol. 2022. PMID: 34637151 Free PMC article. Clinical Trial.

6

Effects of Hepatic Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.

Wang EQ, Le V, O'Gorman M, Tripathy S, Dowty ME, Wang L, Malhotra BK. Wang EQ, et al. Among authors: wang l. J Clin Pharmacol. 2021 Oct;61(10):1311-1323. doi: 10.1002/jcph.1858. Epub 2021 Apr 17. J Clin Pharmacol. 2021. PMID: 33749838 Free PMC article. Clinical Trial.

7

Population PK/PD modeling of low-density lipoprotein cholesterol response in hypercholesterolemic participants following administration of bococizumab, a potent anti-PCSK9 monoclonal antibody.

Wang EQ, Kaila N, Plowchalk D, Gibiansky L, Yunis C, Sweeney K. Wang EQ, et al. CPT Pharmacometrics Syst Pharmacol. 2023 Dec;12(12):2013-2026. doi: 10.1002/psp4.13050. Epub 2023 Nov 22. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37994400 Free PMC article.

8

Comparative Pharmacokinetics and Pharmacodynamics of Bococizumab Following a Single Subcutaneous Injection Using Drug Substance Manufactured at Two Sites or Administration via Two Different Devices.

Wang EQ, Plotka A, Salageanu J, Baltrukonis D, Mridha K, Frederich R, Sullivan BE. Wang EQ, et al. Clin Pharmacol Drug Dev. 2019 Jan;8(1):40-48. doi: 10.1002/cpdd.454. Epub 2018 Apr 24. Clin Pharmacol Drug Dev. 2019. PMID: 29688615 Clinical Trial.

9

Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants.

Fossa AA, Gorczyca W, Wisialowski T, Yasgar A, Wang E, Crimin K, Volberg W, Zhou J. Fossa AA, et al. J Pharmacol Toxicol Methods. 2007 Jan-Feb;55(1):78-85. doi: 10.1016/j.vascn.2006.03.007. Epub 2006 Apr 25. J Pharmacol Toxicol Methods. 2007. PMID: 16678449

10

Dose-escalating study of the pharmacokinetics and tolerability of fesoterodine in children with overactive bladder.

Malhotra B, El-Tahtawy A, Wang EQ, Darekar A, Cossons N, Crook TJ, Scholfield D, Reddy P. Malhotra B, et al. Among authors: wang eq. J Pediatr Urol. 2012 Aug;8(4):336-42. doi: 10.1016/j.jpurol.2012.02.008. Epub 2012 Mar 13. J Pediatr Urol. 2012. PMID: 22417681 Clinical Trial.

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