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Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration.
Soderquist RG, Sloane EM, Loram LC, Harrison JA, Dengler EC, Johnson SM, Amer LD, Young CS, Lewis MT, Poole S, Frank MG, Watkins LR, Milligan ED, Mahoney MJ. Soderquist RG, et al. Among authors: poole s. Pharm Res. 2010 May;27(5):841-54. doi: 10.1007/s11095-010-0077-y. Epub 2010 Mar 12. Pharm Res. 2010. PMID: 20224990 Free PMC article.
Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain.
Sloane E, Langer S, Jekich B, Mahoney J, Hughes T, Frank M, Seibert W, Huberty G, Coats B, Harrison J, Klinman D, Poole S, Maier S, Johnson K, Chavez R, Watkins LR, Leinwand L, Milligan E. Sloane E, et al. Among authors: poole s. Gene Ther. 2009 Oct;16(10):1210-22. doi: 10.1038/gt.2009.79. Epub 2009 Jul 2. Gene Ther. 2009. PMID: 19571887 Free PMC article.
Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain.
Loram LC, Harrison JA, Sloane EM, Hutchinson MR, Sholar P, Taylor FR, Berkelhammer D, Coats BD, Poole S, Milligan ED, Maier SF, Rieger J, Watkins LR. Loram LC, et al. Among authors: poole s. J Neurosci. 2009 Nov 4;29(44):14015-25. doi: 10.1523/JNEUROSCI.3447-09.2009. J Neurosci. 2009. PMID: 19890011 Free PMC article.
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.
Hutchinson MR, Coats BD, Lewis SS, Zhang Y, Sprunger DB, Rezvani N, Baker EM, Jekich BM, Wieseler JL, Somogyi AA, Martin D, Poole S, Judd CM, Maier SF, Watkins LR. Hutchinson MR, et al. Among authors: poole s. Brain Behav Immun. 2008 Nov;22(8):1178-89. doi: 10.1016/j.bbi.2008.05.004. Epub 2008 Jul 2. Brain Behav Immun. 2008. PMID: 18599265 Free PMC article.
Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide.
Chacur M, Milligan ED, Sloan EM, Wieseler-Frank J, Barrientos RM, Martin D, Poole S, Lomonte B, Gutiérrez JM, Maier SF, Cury Y, Watkins LR. Chacur M, et al. Among authors: poole s. Pain. 2004 Mar;108(1-2):180-91. doi: 10.1016/j.pain.2003.12.023. Pain. 2004. PMID: 15109522
588 results