Tolonen A - Search Results

1

Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail.

Sevior DK, Hokkanen J, Tolonen A, Abass K, Tursas L, Pelkonen O, Ahokas JT. Sevior DK, et al. Among authors: tolonen a. Xenobiotica. 2010 Apr;40(4):245-54. doi: 10.3109/00498251003592683. Xenobiotica. 2010. PMID: 20218935

2

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone.

Korhonen T, Turpeinen M, Tolonen A, Laine K, Pelkonen O. Korhonen T, et al. Among authors: tolonen a. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66. doi: 10.1016/j.jsbmb.2007.09.025. Epub 2008 Feb 15. J Steroid Biochem Mol Biol. 2008. PMID: 18356043

3

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells.

Turpeinen M, Tolonen A, Chesne C, Guillouzo A, Uusitalo J, Pelkonen O. Turpeinen M, et al. Among authors: tolonen a. Toxicol In Vitro. 2009 Jun;23(4):748-53. doi: 10.1016/j.tiv.2009.03.008. Epub 2009 Mar 26. Toxicol In Vitro. 2009. PMID: 19328226

4

Comparison of metabolic stability and metabolite identification of 55 ECVAM/ICCVAM validation compounds between human and rat liver homogenates and microsomes - a preliminary analysis.

Pelkonen O, Tolonen A, Rousu T, Tursas L, Turpeinen M, Hokkanen J, Uusitalo J, Bouvier d'Yvoire M, Coecke S. Pelkonen O, et al. Among authors: tolonen a. ALTEX. 2009;26(3):214-22. doi: 10.14573/altex.2009.3.214. ALTEX. 2009. PMID: 19907907 Free article.

5

Cytochrome P450 (CYP) inhibition screening: comparison of three tests.

Turpeinen M, Korhonen LE, Tolonen A, Uusitalo J, Juvonen R, Raunio H, Pelkonen O. Turpeinen M, et al. Among authors: tolonen a. Eur J Pharm Sci. 2006 Oct 1;29(2):130-8. doi: 10.1016/j.ejps.2006.06.005. Epub 2006 Jun 27. Eur J Pharm Sci. 2006. PMID: 16890411

6

In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies.

Tolonen A, Petsalo A, Turpeinen M, Uusitalo J, Pelkonen O. Tolonen A, et al. J Mass Spectrom. 2007 Jul;42(7):960-6. doi: 10.1002/jms.1239. J Mass Spectrom. 2007. PMID: 17565714

7

Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column.

Petsalo A, Turpeinen M, Pelkonen O, Tolonen A. Petsalo A, et al. Among authors: tolonen a. J Chromatogr A. 2008 Dec 26;1215(1-2):107-15. doi: 10.1016/j.chroma.2008.10.122. Epub 2008 Nov 7. J Chromatogr A. 2008. PMID: 19019380

8

Analytical challenges for conducting rapid metabolism characterization for QIVIVE.

Tolonen A, Pelkonen O. Tolonen A, et al. Toxicology. 2015 Jun 5;332:20-9. doi: 10.1016/j.tox.2013.08.010. Epub 2013 Aug 28. Toxicology. 2015. PMID: 23994130 Review.

9

Tandem mass spectrometric analysis of S- and N-linked glutathione conjugates of pulegone and menthofuran and identification of P450 enzymes mediating their formation.

Lassila T, Mattila S, Turpeinen M, Pelkonen O, Tolonen A. Lassila T, et al. Among authors: tolonen a. Rapid Commun Mass Spectrom. 2016 Apr 15;30(7):917-26. doi: 10.1002/rcm.7518. Rapid Commun Mass Spectrom. 2016. PMID: 26969934

10

Timolol metabolism in human liver microsomes is mediated principally by CYP2D6.

Volotinen M, Turpeinen M, Tolonen A, Uusitalo J, Mäenpää J, Pelkonen O. Volotinen M, et al. Among authors: tolonen a. Drug Metab Dispos. 2007 Jul;35(7):1135-41. doi: 10.1124/dmd.106.012906. Epub 2007 Apr 12. Drug Metab Dispos. 2007. PMID: 17431033

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