Akita R - Search Results

1

Spatial control of EGF receptor activation by reversible dimerization on living cells.

Chung I, Akita R, Vandlen R, Toomre D, Schlessinger J, Mellman I. Chung I, et al. Among authors: akita r. Nature. 2010 Apr 1;464(7289):783-7. doi: 10.1038/nature08827. Epub 2010 Mar 7. Nature. 2010. PMID: 20208517

2

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

Sliwkowski MX, Schaefer G, Akita RW, Lofgren JA, Fitzpatrick VD, Nuijens A, Fendly BM, Cerione RA, Vandlen RL, Carraway KL 3rd. Sliwkowski MX, et al. Among authors: akita rw. J Biol Chem. 1994 May 20;269(20):14661-5. J Biol Chem. 1994. PMID: 7514177 Free article.

3

High cell-surface density of HER2 deforms cell membranes.

Chung I, Reichelt M, Shao L, Akita RW, Koeppen H, Rangell L, Schaefer G, Mellman I, Sliwkowski MX. Chung I, et al. Among authors: akita rw. Nat Commun. 2016 Sep 7;7:12742. doi: 10.1038/ncomms12742. Nat Commun. 2016. PMID: 27599456 Free PMC article.

4

The erbB3 gene product is a receptor for heregulin.

Carraway KL 3rd, Sliwkowski MX, Akita R, Platko JV, Guy PM, Nuijens A, Diamonti AJ, Vandlen RL, Cantley LC, Cerione RA. Carraway KL 3rd, et al. Among authors: akita r. J Biol Chem. 1994 May 13;269(19):14303-6. J Biol Chem. 1994. PMID: 8188716 Free article.

5

Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.

Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Brush J, Godowski PJ. Zhang D, et al. Among authors: akita r. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9562-7. doi: 10.1073/pnas.94.18.9562. Proc Natl Acad Sci U S A. 1997. PMID: 9275162 Free PMC article.

6

A discrete three-amino acid segment (LVI) at the C-terminal end of kinase-impaired ErbB3 is required for transactivation of ErbB2.

Schaefer G, Akita RW, Sliwkowski MX. Schaefer G, et al. Among authors: akita rw. J Biol Chem. 1999 Jan 8;274(2):859-66. doi: 10.1074/jbc.274.2.859. J Biol Chem. 1999. PMID: 9873025 Free article.

7

Binding specificities and affinities of egf domains for ErbB receptors.

Jones JT, Akita RW, Sliwkowski MX. Jones JT, et al. Among authors: akita rw. FEBS Lett. 1999 Mar 26;447(2-3):227-31. doi: 10.1016/s0014-5793(99)00283-5. FEBS Lett. 1999. PMID: 10214951 Free article.

8

Structural requirements for ErbB2 transactivation.

Penuel E, Schaefer G, Akita RW, Sliwkowski MX. Penuel E, et al. Among authors: akita rw. Semin Oncol. 2001 Dec;28(6 Suppl 18):36-42. Semin Oncol. 2001. PMID: 11774204 Review.

9

Identification of a region within the ErbB2/HER2 intracellular domain that is necessary for ligand-independent association.

Penuel E, Akita RW, Sliwkowski MX. Penuel E, et al. J Biol Chem. 2002 Aug 9;277(32):28468-73. doi: 10.1074/jbc.M202510200. Epub 2002 May 8. J Biol Chem. 2002. PMID: 12000754 Free article.

10

Erlotinib directly inhibits HER2 kinase activation and downstream signaling events in intact cells lacking epidermal growth factor receptor expression.

Schaefer G, Shao L, Totpal K, Akita RW. Schaefer G, et al. Cancer Res. 2007 Feb 1;67(3):1228-38. doi: 10.1158/0008-5472.CAN-06-3493. Cancer Res. 2007. PMID: 17283159

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