Parkinson A - Search Results

1

System-dependent outcomes during the evaluation of drug candidates as inhibitors of cytochrome P450 (CYP) and uridine diphosphate glucuronosyltransferase (UGT) enzymes: human hepatocytes versus liver microsomes versus recombinant enzymes.

Parkinson A, Kazmi F, Buckley DB, Yerino P, Ogilvie BW, Paris BL. Parkinson A, et al. Drug Metab Pharmacokinet. 2010;25(1):16-27. doi: 10.2133/dmpk.25.16. Drug Metab Pharmacokinet. 2010. PMID: 20208386 Free article. Review.

2

In vitro inhibition and induction of human liver cytochrome p450 enzymes by milnacipran.

Paris BL, Ogilvie BW, Scheinkoenig JA, Ndikum-Moffor F, Gibson R, Parkinson A. Paris BL, et al. Among authors: parkinson a. Drug Metab Dispos. 2009 Oct;37(10):2045-54. doi: 10.1124/dmd.109.028274. Epub 2009 Jul 16. Drug Metab Dispos. 2009. PMID: 19608694

3

An evaluation of the dilution method for identifying metabolism-dependent inhibitors of cytochrome P450 enzymes.

Parkinson A, Kazmi F, Buckley DB, Yerino P, Paris BL, Holsapple J, Toren P, Otradovec SM, Ogilvie BW. Parkinson A, et al. Drug Metab Dispos. 2011 Aug;39(8):1370-87. doi: 10.1124/dmd.111.038596. Epub 2011 Apr 27. Drug Metab Dispos. 2011. PMID: 21525169

4

The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: implications for coadministration with clopidogrel.

Ogilvie BW, Yerino P, Kazmi F, Buckley DB, Rostami-Hodjegan A, Paris BL, Toren P, Parkinson A. Ogilvie BW, et al. Among authors: parkinson a. Drug Metab Dispos. 2011 Nov;39(11):2020-33. doi: 10.1124/dmd.111.041293. Epub 2011 Jul 27. Drug Metab Dispos. 2011. PMID: 21795468

5

Metabolism-dependent inhibition of CYP3A4 by lapatinib: evidence for formation of a metabolic intermediate complex with a nitroso/oxime metabolite formed via a nitrone intermediate.

Barbara JE, Kazmi F, Parkinson A, Buckley DB. Barbara JE, et al. Among authors: parkinson a. Drug Metab Dispos. 2013 May;41(5):1012-22. doi: 10.1124/dmd.113.051151. Epub 2013 Feb 12. Drug Metab Dispos. 2013. PMID: 23404373

6

Anti-CD28 monoclonal antibody-stimulated cytokines released from blood suppress CYP1A2, CYP2B6, and CYP3A4 in human hepatocytes in vitro.

Czerwiński M, Kazmi F, Parkinson A, Buckley DB. Czerwiński M, et al. Among authors: parkinson a. Drug Metab Dispos. 2015 Jan;43(1):42-52. doi: 10.1124/dmd.114.060186. Epub 2014 Oct 17. Drug Metab Dispos. 2015. PMID: 25326287

7

A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.

Kazmi F, Barbara JE, Yerino P, Parkinson A. Kazmi F, et al. Among authors: parkinson a. Drug Metab Dispos. 2015 Apr;43(4):523-33. doi: 10.1124/dmd.114.062620. Epub 2015 Jan 16. Drug Metab Dispos. 2015. PMID: 25595597

8

Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor.

Kazmi F, Yerino P, Barbara JE, Parkinson A. Kazmi F, et al. Among authors: parkinson a. Drug Metab Dispos. 2015 Sep;43(9):1294-302. doi: 10.1124/dmd.115.065011. Epub 2015 Jul 1. Drug Metab Dispos. 2015. PMID: 26135009

9

The Reliability of Estimating Ki Values for Direct, Reversible Inhibition of Cytochrome P450 Enzymes from Corresponding IC50 Values: A Retrospective Analysis of 343 Experiments.

Haupt LJ, Kazmi F, Ogilvie BW, Buckley DB, Smith BD, Leatherman S, Paris B, Parkinson O, Parkinson A. Haupt LJ, et al. Among authors: parkinson a, parkinson o. Drug Metab Dispos. 2015 Nov;43(11):1744-50. doi: 10.1124/dmd.115.066597. Epub 2015 Sep 9. Drug Metab Dispos. 2015. PMID: 26354951

10

An Assessment of the In Vitro Inhibition of Cytochrome P450 Enzymes, UDP-Glucuronosyltransferases, and Transporters by Phosphodiester- or Phosphorothioate-Linked Oligonucleotides.

Kazmi F, Yerino P, McCoy C, Parkinson A, Buckley DB, Ogilvie BW. Kazmi F, et al. Among authors: parkinson a. Drug Metab Dispos. 2018 Aug;46(8):1066-1074. doi: 10.1124/dmd.118.081729. Epub 2018 May 7. Drug Metab Dispos. 2018. PMID: 29735754

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