Brown SJ - Search Results

1

Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9).

Bachovchin DA, Wolfe MR, Masuda K, Brown SJ, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF. Bachovchin DA, et al. Among authors: brown sj. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2254-8. doi: 10.1016/j.bmcl.2010.02.011. Epub 2010 Feb 6. Bioorg Med Chem Lett. 2010. PMID: 20207142 Free PMC article.

2

SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P₄) receptor.

Urbano M, Guerrero M, Zhao J, Velaparthi S, Schaeffer MT, Brown S, Rosen H, Roberts E. Urbano M, et al. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5470-4. doi: 10.1016/j.bmcl.2011.06.132. Epub 2011 Jul 13. Bioorg Med Chem Lett. 2011. PMID: 21783362 Free PMC article.

3

Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype.

Urbano M, Guerrero M, Velaparthi S, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E. Urbano M, et al. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6739-45. doi: 10.1016/j.bmcl.2011.09.049. Epub 2011 Sep 20. Bioorg Med Chem Lett. 2011. PMID: 21982495 Free PMC article.

4

Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists.

Guerrero M, Urbano M, Zhao J, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E. Guerrero M, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):537-42. doi: 10.1016/j.bmcl.2011.10.096. Epub 2011 Nov 4. Bioorg Med Chem Lett. 2012. PMID: 22119461 Free PMC article.

5

Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7).

Urbano M, Guerrero M, Zhao J, Velaparthi S, Saldanha SA, Chase P, Wang Z, Civelli O, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E. Urbano M, et al. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7135-41. doi: 10.1016/j.bmcl.2012.09.074. Epub 2012 Oct 2. Bioorg Med Chem Lett. 2012. PMID: 23079522 Free PMC article.

6

Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist.

Guerrero M, Poddutoori R, Urbano M, Peng X, Spicer TP, Chase PS, Hodder PS, Schaeffer MT, Brown S, Rosen H, Roberts E. Guerrero M, et al. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6346-9. doi: 10.1016/j.bmcl.2013.09.075. Epub 2013 Oct 1. Bioorg Med Chem Lett. 2013. PMID: 24135724 Free PMC article.

7

Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes.

Bachovchin DA, Brown SJ, Rosen H, Cravatt BF. Bachovchin DA, et al. Among authors: brown sj. Nat Biotechnol. 2009 Apr;27(4):387-94. doi: 10.1038/nbt.1531. Epub 2009 Mar 29. Nat Biotechnol. 2009. PMID: 19329999 Free PMC article.

8

Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.

Bachovchin DA, Zuhl AM, Speers AE, Wolfe MR, Weerapana E, Brown SJ, Rosen H, Cravatt BF. Bachovchin DA, et al. Among authors: brown sj. J Med Chem. 2011 Jul 28;54(14):5229-36. doi: 10.1021/jm200502u. Epub 2011 Jun 30. J Med Chem. 2011. PMID: 21639134 Free PMC article.

9

Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization.

Dillon MB, Bachovchin DA, Brown SJ, Finn MG, Rosen H, Cravatt BF, Mowen KA. Dillon MB, et al. Among authors: brown sj. ACS Chem Biol. 2012 Jul 20;7(7):1198-204. doi: 10.1021/cb300024c. Epub 2012 Apr 20. ACS Chem Biol. 2012. PMID: 22506763 Free PMC article.

10

Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2).

Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF. Nagano JM, et al. Among authors: brown sj. Bioorg Med Chem Lett. 2013 Feb 1;23(3):839-43. doi: 10.1016/j.bmcl.2012.11.061. Epub 2012 Dec 2. Bioorg Med Chem Lett. 2013. PMID: 23260346 Free PMC article.

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