Tonge PJ - Search Results

1

Radiosynthesis and bioimaging of the tuberculosis chemotherapeutics isoniazid, rifampicin and pyrazinamide in baboons.

Liu L, Xu Y, Shea C, Fowler JS, Hooker JM, Tonge PJ. Liu L, et al. Among authors: tonge pj. J Med Chem. 2010 Apr 8;53(7):2882-91. doi: 10.1021/jm901858n. J Med Chem. 2010. PMID: 20205479 Free PMC article.

2

Inhibition of the bacterial enoyl reductase FabI by triclosan: a structure-reactivity analysis of FabI inhibition by triclosan analogues.

Sivaraman S, Sullivan TJ, Johnson F, Novichenok P, Cui G, Simmerling C, Tonge PJ. Sivaraman S, et al. Among authors: tonge pj. J Med Chem. 2004 Jan 29;47(3):509-18. doi: 10.1021/jm030182i. J Med Chem. 2004. PMID: 14736233

3

Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents.

Huang Q, Kirikae F, Kirikae T, Pepe A, Amin A, Respicio L, Slayden RA, Tonge PJ, Ojima I. Huang Q, et al. Among authors: tonge pj. J Med Chem. 2006 Jan 26;49(2):463-6. doi: 10.1021/jm050920y. J Med Chem. 2006. PMID: 16420032 Free PMC article.

4

Insight through molecular mechanics Poisson-Boltzmann surface area calculations into the binding affinity of triclosan and three analogues for FabI, the E. coli enoyl reductase.

Rafi SB, Cui G, Song K, Cheng X, Tonge PJ, Simmerling C. Rafi SB, et al. Among authors: tonge pj. J Med Chem. 2006 Jul 27;49(15):4574-80. doi: 10.1021/jm060222t. J Med Chem. 2006. PMID: 16854062

5

Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosis.

Tonge PJ, Kisker C, Slayden RA. Tonge PJ, et al. Curr Top Med Chem. 2007;7(5):489-98. doi: 10.2174/156802607780059781. Curr Top Med Chem. 2007. PMID: 17346194 Review.

6

FtsZ: a novel target for tuberculosis drug discovery.

Huang Q, Tonge PJ, Slayden RA, Kirikae T, Ojima I. Huang Q, et al. Among authors: tonge pj. Curr Top Med Chem. 2007;7(5):527-43. doi: 10.2174/156802607780059790. Curr Top Med Chem. 2007. PMID: 17346197 Review.

7

Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors.

am Ende CW, Knudson SE, Liu N, Childs J, Sullivan TJ, Boyne M, Xu H, Gegina Y, Knudson DL, Johnson F, Peloquin CA, Slayden RA, Tonge PJ. am Ende CW, et al. Among authors: tonge pj. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. doi: 10.1016/j.bmcl.2008.04.038. Epub 2008 Apr 18. Bioorg Med Chem Lett. 2008. PMID: 18457948 Free PMC article.

8

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Li X, Liu N, Zhang H, Knudson SE, Slayden RA, Tonge PJ. Li X, et al. Among authors: tonge pj. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6306-9. doi: 10.1016/j.bmcl.2010.08.076. Epub 2010 Aug 21. Bioorg Med Chem Lett. 2010. PMID: 20850304 Free PMC article.

9

Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.

Kumar K, Awasthi D, Lee SY, Zanardi I, Ruzsicska B, Knudson S, Tonge PJ, Slayden RA, Ojima I. Kumar K, et al. Among authors: tonge pj. J Med Chem. 2011 Jan 13;54(1):374-81. doi: 10.1021/jm1012006. Epub 2010 Dec 2. J Med Chem. 2011. PMID: 21126020 Free PMC article.

10

Discovery of anti-TB agents that target the cell-division protein FtsZ.

Kumar K, Awasthi D, Berger WT, Tonge PJ, Slayden RA, Ojima I. Kumar K, et al. Among authors: tonge pj. Future Med Chem. 2010 Aug;2(8):1305-23. doi: 10.4155/fmc.10.220. Future Med Chem. 2010. PMID: 21339840 Free PMC article. Review.

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