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Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.
Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, Zweckstetter M, Masliah E, Lashuel HA. Paleologou KE, et al. Among authors: lashuel ha. J Neurosci. 2010 Mar 3;30(9):3184-98. doi: 10.1523/JNEUROSCI.5922-09.2010. J Neurosci. 2010. PMID: 20203178 Free PMC article.
The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor.
El-Turk F, Cascella M, Ouertatani-Sakouhi H, Narayanan RL, Leng L, Bucala R, Zweckstetter M, Rothlisberger U, Lashuel HA. El-Turk F, et al. Among authors: lashuel ha. Biochemistry. 2008 Oct 7;47(40):10740-56. doi: 10.1021/bi800603x. Epub 2008 Sep 17. Biochemistry. 2008. PMID: 18795803 Free PMC article.
222 results