Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165.
Hashimoto G, Inoki I, Fujii Y, Aoki T, Ikeda E, Okada Y.
Hashimoto G, et al. Among authors: ikeda e.
J Biol Chem. 2002 Sep 27;277(39):36288-95. doi: 10.1074/jbc.M201674200. Epub 2002 Jul 11.
J Biol Chem. 2002.
PMID: 12114504
Free article.
We have recently demonstrated that VEGF(165), one of the VEGF isoforms, binds connective tissue growth factor (CTGF) and that its angiogenic activity is inhibited in the VEGF(165).CTGF complex form (Inoki, I., Shiomi, T., Hashimoto, G., Enomoto, H., Nakamura, H., Makino, K., I …
We have recently demonstrated that VEGF(165), one of the VEGF isoforms, binds connective tissue growth factor (CTGF) and that its angiogenic …