Klunk WE - Search Results

1

11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study.

Rinne JO, Brooks DJ, Rossor MN, Fox NC, Bullock R, Klunk WE, Mathis CA, Blennow K, Barakos J, Okello AA, Rodriguez Martinez de Liano S, Liu E, Koller M, Gregg KM, Schenk D, Black R, Grundman M. Rinne JO, et al. Among authors: klunk we. Lancet Neurol. 2010 Apr;9(4):363-72. doi: 10.1016/S1474-4422(10)70043-0. Epub 2010 Feb 26. Lancet Neurol. 2010. PMID: 20189881 Clinical Trial.

2

Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.

Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Mathis CA. Klunk WE, et al. Life Sci. 2001 Aug 17;69(13):1471-84. doi: 10.1016/s0024-3205(01)01232-2. Life Sci. 2001. PMID: 11554609

3

A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.

Mathis CA, Bacskai BJ, Kajdasz ST, McLellan ME, Frosch MP, Hyman BT, Holt DP, Wang Y, Huang GF, Debnath ML, Klunk WE. Mathis CA, et al. Among authors: klunk we. Bioorg Med Chem Lett. 2002 Feb 11;12(3):295-8. doi: 10.1016/s0960-894x(01)00734-x. Bioorg Med Chem Lett. 2002. PMID: 11814781

4

Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease.

Wang Y, Klunk WE, Huang GF, Debnath ML, Holt DP, Mathis CA. Wang Y, et al. Among authors: klunk we. J Mol Neurosci. 2002 Aug-Oct;19(1-2):11-6. doi: 10.1007/s12031-002-0004-8. J Mol Neurosci. 2002. PMID: 12212766

5

Imaging amyloid-beta deposits in vivo.

Bacskai BJ, Klunk WE, Mathis CA, Hyman BT. Bacskai BJ, et al. Among authors: klunk we. J Cereb Blood Flow Metab. 2002 Sep;22(9):1035-41. doi: 10.1097/00004647-200209000-00001. J Cereb Blood Flow Metab. 2002. PMID: 12218409 Review.

6

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.

Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT. Klunk WE, et al. J Neuropathol Exp Neurol. 2002 Sep;61(9):797-805. doi: 10.1093/jnen/61.9.797. J Neuropathol Exp Neurol. 2002. PMID: 12230326

7

The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component.

Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Shao L, Hamilton RL, Ikonomovic MD, DeKosky ST, Mathis CA. Klunk WE, et al. J Neurosci. 2003 Mar 15;23(6):2086-92. doi: 10.1523/JNEUROSCI.23-06-02086.2003. J Neurosci. 2003. PMID: 12657667 Free PMC article.

8

Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.

Mathis CA, Wang Y, Holt DP, Huang GF, Debnath ML, Klunk WE. Mathis CA, et al. Among authors: klunk we. J Med Chem. 2003 Jun 19;46(13):2740-54. doi: 10.1021/jm030026b. J Med Chem. 2003. PMID: 12801237

9

Effects of lipophilicity on the affinity and nonspecific binding of iodinated benzothiazole derivatives.

Wang Y, Mathis CA, Huang GF, Debnath ML, Holt DP, Shao L, Klunk WE. Wang Y, et al. Among authors: klunk we. J Mol Neurosci. 2003;20(3):255-60. doi: 10.1385/JMN:20:3:255. J Mol Neurosci. 2003. PMID: 14501005

10

Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice.

Bacskai BJ, Hickey GA, Skoch J, Kajdasz ST, Wang Y, Huang GF, Mathis CA, Klunk WE, Hyman BT. Bacskai BJ, et al. Among authors: klunk we. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12462-7. doi: 10.1073/pnas.2034101100. Epub 2003 Sep 29. Proc Natl Acad Sci U S A. 2003. PMID: 14517353 Free PMC article.

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