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Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress.
Brouwers O, Niessen PM, Haenen G, Miyata T, Brownlee M, Stehouwer CD, De Mey JG, Schalkwijk CG. Brouwers O, et al. Among authors: brownlee m. Diabetologia. 2010 May;53(5):989-1000. doi: 10.1007/s00125-010-1677-0. Epub 2010 Feb 26. Diabetologia. 2010. PMID: 20186387 Free PMC article.
Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes.
Brouwers O, Niessen PM, Miyata T, Østergaard JA, Flyvbjerg A, Peutz-Kootstra CJ, Sieber J, Mundel PH, Brownlee M, Janssen BJ, De Mey JG, Stehouwer CD, Schalkwijk CG. Brouwers O, et al. Among authors: brownlee m. Diabetologia. 2014 Jan;57(1):224-35. doi: 10.1007/s00125-013-3088-5. Epub 2013 Oct 26. Diabetologia. 2014. PMID: 24162587
Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype.
Hanssen NM, Wouters K, Huijberts MS, Gijbels MJ, Sluimer JC, Scheijen JL, Heeneman S, Biessen EA, Daemen MJ, Brownlee M, de Kleijn DP, Stehouwer CD, Pasterkamp G, Schalkwijk CG. Hanssen NM, et al. Among authors: brownlee m. Eur Heart J. 2014 May;35(17):1137-46. doi: 10.1093/eurheartj/eht402. Epub 2013 Oct 14. Eur Heart J. 2014. PMID: 24126878
Oxidative stress and diabetic complications.
Giacco F, Brownlee M. Giacco F, et al. Among authors: brownlee m. Circ Res. 2010 Oct 29;107(9):1058-70. doi: 10.1161/CIRCRESAHA.110.223545. Circ Res. 2010. PMID: 21030723 Free PMC article. Review.
Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy.
Lin J, Bierhaus A, Bugert P, Dietrich N, Feng Y, Vom Hagen F, Nawroth P, Brownlee M, Hammes HP. Lin J, et al. Among authors: brownlee m. Diabetologia. 2006 May;49(5):1089-96. doi: 10.1007/s00125-006-0174-y. Epub 2006 Mar 7. Diabetologia. 2006. PMID: 16520919
236 results