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Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation.
Harmsze A, van Werkum JW, Bouman HJ, Ruven HJ, Breet NJ, Ten Berg JM, Hackeng CM, Tjoeng MM, Klungel OH, de Boer A, Deneer VH. Harmsze A, et al. Among authors: bouman hj. Pharmacogenet Genomics. 2010 Jan;20(1):18-25. doi: 10.1097/FPC.0b013e328333dafe. Pharmacogenet Genomics. 2010. PMID: 19934793
Common variation in the platelet receptor P2RY12 gene is associated with residual on-clopidogrel platelet reactivity in patients undergoing elective percutaneous coronary interventions.
Rudez G, Bouman HJ, van Werkum JW, Leebeek FW, Kruit A, Ruven HJ, ten Berg JM, de Maat MP, Hackeng CM. Rudez G, et al. Among authors: bouman hj. Circ Cardiovasc Genet. 2009 Oct;2(5):515-21. doi: 10.1161/CIRCGENETICS.109.861799. Epub 2009 Jul 24. Circ Cardiovasc Genet. 2009. PMID: 20031628
Paraoxonase-1 is a major determinant of clopidogrel efficacy.
Bouman HJ, Schömig E, van Werkum JW, Velder J, Hackeng CM, Hirschhäuser C, Waldmann C, Schmalz HG, ten Berg JM, Taubert D. Bouman HJ, et al. Nat Med. 2011 Jan;17(1):110-6. doi: 10.1038/nm.2281. Epub 2010 Dec 19. Nat Med. 2011. PMID: 21170047
39 results