Jones TK - Search Results

1

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions.

Wiener JJ, Wickboldt AT Jr, Wiener DK, Lee-Dutra A, Edwards JP, Karlsson L, Nguyen S, Sun S, Jones TK, Grice CA. Wiener JJ, et al. Among authors: jones tk. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2375-8. doi: 10.1016/j.bmcl.2010.01.104. Epub 2010 Feb 1. Bioorg Med Chem Lett. 2010. PMID: 20171097

2

Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: synthesis and preliminary SAR analysis.

Gomez L, Hack MD, Wu J, Wiener JJ, Venkatesan H, Santillán A Jr, Pippel DJ, Mani N, Morrow BJ, Motley ST, Shaw KJ, Wolin R, Grice CA, Jones TK. Gomez L, et al. Among authors: jones tk. Bioorg Med Chem Lett. 2007 May 15;17(10):2723-7. doi: 10.1016/j.bmcl.2007.03.003. Epub 2007 Mar 6. Bioorg Med Chem Lett. 2007. PMID: 17368897

3

Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains.

Wiener JJ, Gomez L, Venkatesan H, Santillán A Jr, Allison BD, Schwarz KL, Shinde S, Tang L, Hack MD, Morrow BJ, Motley ST, Goldschmidt RM, Shaw KJ, Jones TK, Grice CA. Wiener JJ, et al. Among authors: jones tk. Bioorg Med Chem Lett. 2007 May 15;17(10):2718-22. doi: 10.1016/j.bmcl.2007.03.004. Epub 2007 Mar 6. Bioorg Med Chem Lett. 2007. PMID: 17382544

4

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.

Lee-Dutra A, Wiener DK, Arienti KL, Liu J, Mani N, Ameriks MK, Axe FU, Gebauer D, Desai PJ, Nguyen S, Randal M, Thurmond RL, Sun S, Karlsson L, Edwards JP, Jones TK, Grice CA. Lee-Dutra A, et al. Among authors: jones tk. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2370-4. doi: 10.1016/j.bmcl.2010.01.108. Epub 2010 Jan 28. Bioorg Med Chem Lett. 2010. PMID: 20153648

5

Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors.

Wiener DK, Lee-Dutra A, Bembenek S, Nguyen S, Thurmond RL, Sun S, Karlsson L, Grice CA, Jones TK, Edwards JP. Wiener DK, et al. Among authors: jones tk. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2379-82. doi: 10.1016/j.bmcl.2010.01.103. Epub 2010 Feb 8. Bioorg Med Chem Lett. 2010. PMID: 20188543

6

Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators.

Zhi L, Tegley CM, Pio B, Edwards JP, Jones TK, Marschke KB, Mais DE, Risek B, Schrader WT. Zhi L, et al. Among authors: jones tk. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2071-4. doi: 10.1016/s0960-894x(03)00255-5. Bioorg Med Chem Lett. 2003. PMID: 12781197

7

Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.

Zhi L, Ringgenberg JD, Edwards JP, Tegley CM, West SJ, Pio B, Motamedi M, Jones TK, Marschke KB, Mais DE, Schrader WT. Zhi L, et al. Among authors: jones tk. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2075-8. doi: 10.1016/s0960-894x(03)00256-7. Bioorg Med Chem Lett. 2003. PMID: 12781198

8

Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist pharmacophore.

Pooley CL, Edwards JP, Goldman ME, Wang MW, Marschke KB, Crombie DL, Jones TK. Pooley CL, et al. Among authors: jones tk. J Med Chem. 1998 Aug 27;41(18):3461-6. doi: 10.1021/jm9801915. J Med Chem. 1998. PMID: 9719599

9

New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone.

Edwards JP, West SJ, Pooley CL, Marschke KB, Farmer LJ, Jones TK. Edwards JP, et al. Among authors: jones tk. Bioorg Med Chem Lett. 1998 Apr 7;8(7):745-50. doi: 10.1016/s0960-894x(98)00107-3. Bioorg Med Chem Lett. 1998. PMID: 9871534

10

5-Alkyl 1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal progesterone receptor modulators.

Zhi L, Tegley CM, Edwards JP, West SJ, Marschke KB, Gottardis MM, Mais DE, Jones TK. Zhi L, et al. Among authors: jones tk. Bioorg Med Chem Lett. 1998 Dec 1;8(23):3365-70. doi: 10.1016/s0960-894x(98)00608-8. Bioorg Med Chem Lett. 1998. PMID: 9873735

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