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1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: a novel series of potent calcium-sensing receptor antagonists.
Widler L, Altmann E, Beerli R, Breitenstein W, Bouhelal R, Buhl T, Gamse R, Gerspacher M, Halleux C, John MR, Lehmann H, Kalb O, Kneissel M, Missbach M, Müller IR, Reidemeister S, Renaud J, Taillardat A, Tommasi R, Weiler S, Wolf RM, Seuwen K. Widler L, et al. Among authors: bouhelal r. J Med Chem. 2010 Mar 11;53(5):2250-63. doi: 10.1021/jm901811v. J Med Chem. 2010. PMID: 20158186
The 7 TM G-protein-coupled receptor target family.
Jacoby E, Bouhelal R, Gerspacher M, Seuwen K. Jacoby E, et al. Among authors: bouhelal r. ChemMedChem. 2006 Aug;1(8):761-82. doi: 10.1002/cmdc.200600134. ChemMedChem. 2006. PMID: 16902930 Review.
Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure.
Velcicky J, Wilcken R, Cotesta S, Janser P, Schlapbach A, Wagner T, Piechon P, Villard F, Bouhelal R, Piller F, Harlfinger S, Stringer R, Fehlmann D, Kaupmann K, Littlewood-Evans A, Haffke M, Gommermann N. Velcicky J, et al. Among authors: bouhelal r. J Med Chem. 2020 Sep 10;63(17):9856-9875. doi: 10.1021/acs.jmedchem.0c01020. Epub 2020 Aug 28. J Med Chem. 2020. PMID: 32856916
Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.
Gee CE, Peterlik D, Neuhäuser C, Bouhelal R, Kaupmann K, Laue G, Uschold-Schmidt N, Feuerbach D, Zimmermann K, Ofner S, Cryan JF, van der Putten H, Fendt M, Vranesic I, Glatthar R, Flor PJ. Gee CE, et al. Among authors: bouhelal r. J Biol Chem. 2014 Apr 18;289(16):10975-10987. doi: 10.1074/jbc.M113.542654. Epub 2014 Mar 4. J Biol Chem. 2014. PMID: 24596089 Free PMC article.
Design and synthesis of selective and potent orally active S1P5 agonists.
Mattes H, Dev KK, Bouhelal R, Barske C, Gasparini F, Guerini D, Mir AK, Orain D, Osinde M, Picard A, Dubois C, Tasdelen E, Haessig S. Mattes H, et al. Among authors: bouhelal r. ChemMedChem. 2010 Oct 4;5(10):1693-6. doi: 10.1002/cmdc.201000253. ChemMedChem. 2010. PMID: 20815011 No abstract available.
30 results