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Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death.
Vosler PS, Gao Y, Brennan CS, Yanagiya A, Gan Y, Cao G, Zhang F, Morley SJ, Sonenberg N, Bennett MV, Chen J. Vosler PS, et al. Among authors: chen j. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18102-7. doi: 10.1073/pnas.1112635108. Epub 2011 Oct 17. Proc Natl Acad Sci U S A. 2011. PMID: 22006312 Free PMC article.
Potential molecular targets for translational stroke research.
Vosler PS, Chen J. Vosler PS, et al. Among authors: chen j. Stroke. 2009 Mar;40(3 Suppl):S119-20. doi: 10.1161/STROKEAHA.108.533109. Epub 2008 Dec 8. Stroke. 2009. PMID: 19064800 Free PMC article. Review. No abstract available.
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