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The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo.
Rhodin MHJ, Reyes AC, Balakrishnan A, Bisht N, Kelly NM, Gibbons JS, Lloyd J, Vaine M, Cressey T, Crepeau M, Shen R, Manalo N, Castillo J, Levene RE, Leonard D, Zang T, Jiang L, Daniels K, Cox RM, Lieber CM, Wolf JD, Plemper RK, Leist SR, Scobey T, Baric RS, Wang G, Goodwin B, Or YS. Rhodin MHJ, et al. Among authors: lieber cm. Nat Commun. 2024 Aug 1;15(1):6503. doi: 10.1038/s41467-024-50931-8. Nat Commun. 2024. PMID: 39090095 Free PMC article.
Anti-SARS-CoV-2 antibodies in a nasal spray efficiently block viral transmission between ferrets.
Gildemann K, Tsernant ML, Liivand L, Ennomäe R, Poikalainen V, Lepasalu L, Rom S, Kavak A, Cox RM, Wolf JD, Lieber CM, Plemper RK, Männik A, Ustav M Jr, Ustav M, Gerhold JM. Gildemann K, et al. Among authors: lieber cm. iScience. 2024 Jun 20;27(7):110326. doi: 10.1016/j.isci.2024.110326. eCollection 2024 Jul 19. iScience. 2024. PMID: 39045097 Free PMC article.
Efficacy of late-onset antiviral treatment in immune-compromised hosts with persistent SARS-CoV-2 infection.
Lieber CM, Kang HJ, Sobolik EB, Sticher ZM, Ngo VL, Gewirtz AT, Kolykhalov AA, Natchus MG, Greninger AL, Suthar MS, Plemper RK. Lieber CM, et al. bioRxiv [Preprint]. 2024 May 23:2024.05.23.595478. doi: 10.1101/2024.05.23.595478. bioRxiv. 2024. Update in: J Virol. 2024 Sep 17;98(9):e0090524. doi: 10.1128/jvi.00905-24 PMID: 38826222 Free PMC article. Updated. Preprint.
Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets.
Cox RM, Wolf JD, Lieberman NA, Lieber CM, Kang HJ, Sticher ZM, Yoon JJ, Andrews MK, Govindarajan M, Krueger RE, Sobolik EB, Natchus MG, Gewirtz AT, deSwart RL, Kolykhalov AA, Hekmatyar K, Sakamoto K, Greninger AL, Plemper RK. Cox RM, et al. Among authors: lieber cm. Nat Commun. 2024 Feb 8;15(1):1189. doi: 10.1038/s41467-024-45418-5. Nat Commun. 2024. PMID: 38331906 Free PMC article.
1,006 results