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SPAKling insight into blood pressure regulation.
Castañeda-Bueno M, Gamba G. Castañeda-Bueno M, et al. Among authors: gamba g. EMBO Mol Med. 2010 Feb;2(2):39-41. doi: 10.1002/emmm.200900059. EMBO Mol Med. 2010. PMID: 20112249 Free PMC article.
Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.
Ponce-Coria J, San-Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de Los Heros P, Juárez P, Muñoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G. Ponce-Coria J, et al. Among authors: gamba g. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8458-63. doi: 10.1073/pnas.0802966105. Epub 2008 Jun 11. Proc Natl Acad Sci U S A. 2008. PMID: 18550832 Free PMC article.
Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway.
San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G. San-Cristobal P, et al. Among authors: gamba g. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4384-9. doi: 10.1073/pnas.0813238106. Epub 2009 Feb 24. Proc Natl Acad Sci U S A. 2009. PMID: 19240212 Free PMC article.
A single residue in transmembrane domain 11 defines the different affinity for thiazides between the mammalian and flounder NaCl transporters.
Castañeda-Bueno M, Vázquez N, Bustos-Jaimes I, Hernández D, Rodríguez-Lobato E, Pacheco-Alvarez D, Cariño-Cortés R, Moreno E, Bobadilla NA, Gamba G. Castañeda-Bueno M, et al. Among authors: gamba g. Am J Physiol Renal Physiol. 2010 Nov;299(5):F1111-9. doi: 10.1152/ajprenal.00412.2010. Epub 2010 Aug 18. Am J Physiol Renal Physiol. 2010. PMID: 20719978 Free PMC article.
Hsp72 is an early and sensitive biomarker to detect acute kidney injury.
Barrera-Chimal J, Pérez-Villalva R, Cortés-González C, Ojeda-Cervantes M, Gamba G, Morales-Buenrostro LE, Bobadilla NA. Barrera-Chimal J, et al. Among authors: gamba g. EMBO Mol Med. 2011 Jan;3(1):5-20. doi: 10.1002/emmm.201000105. Epub 2010 Dec 14. EMBO Mol Med. 2011. PMID: 21204265 Free PMC article.
Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner.
Mutig K, Kahl T, Saritas T, Godes M, Persson P, Bates J, Raffi H, Rampoldi L, Uchida S, Hille C, Dosche C, Kumar S, Castañeda-Bueno M, Gamba G, Bachmann S. Mutig K, et al. Among authors: gamba g. J Biol Chem. 2011 Aug 26;286(34):30200-10. doi: 10.1074/jbc.M111.222968. Epub 2011 Jul 7. J Biol Chem. 2011. PMID: 21737451 Free PMC article.
Independent regulation of Na+ and K+ balance by the kidney.
Castañeda-Bueno M, Arroyo JP, Gamba G. Castañeda-Bueno M, et al. Among authors: gamba g. Med Princ Pract. 2012;21(2):101-14. doi: 10.1159/000332580. Epub 2011 Oct 25. Med Princ Pract. 2012. PMID: 22042004 Free article. Review.
464 results