Bhalla K - Search Results

1

Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia.

Lancet JE, Gojo I, Burton M, Quinn M, Tighe SM, Kersey K, Zhong Z, Albitar MX, Bhalla K, Hannah AL, Baer MR. Lancet JE, et al. Among authors: bhalla k. Leukemia. 2010 Apr;24(4):699-705. doi: 10.1038/leu.2009.292. Epub 2010 Jan 28. Leukemia. 2010. PMID: 20111068 Clinical Trial.

2

Phase I study of a continuous infusion of high-dose ara-C in conjunction with a fixed dose of 2'-deoxycytidine (IND 28108) in patients with refractory leukemia: an interim report.

Grant S, Baker M, Bhalla K. Grant S, et al. Among authors: bhalla k. Leukemia. 1993 Dec;7(12):1933-8. Leukemia. 1993. PMID: 8255091 Clinical Trial.

3

Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Brc-Abl-positive acute leukemia cells.

Porosnicu M, Nimmanapalli R, Nguyen D, Worthington E, Perkins C, Bhalla KN. Porosnicu M, et al. Among authors: bhalla kn. Leukemia. 2001 May;15(5):772-8. doi: 10.1038/sj.leu.2402104. Leukemia. 2001. PMID: 11368438

4

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy.

Blagosklonny MV, Fojo T, Bhalla KN, Kim JS, Trepel JB, Figg WD, Rivera Y, Neckers LM. Blagosklonny MV, et al. Among authors: bhalla kn. Leukemia. 2001 Oct;15(10):1537-43. doi: 10.1038/sj.leu.2402257. Leukemia. 2001. PMID: 11587211

5

Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors.

Dorsey JF, Cunnick JM, Lanehart R, Huang M, Kraker AJ, Bhalla KN, Jove R, Wu J. Dorsey JF, et al. Among authors: bhalla kn. Leukemia. 2002 Sep;16(9):1589-95. doi: 10.1038/sj.leu.2402678. Leukemia. 2002. PMID: 12200668

6

Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3.

George P, Bali P, Cohen P, Tao J, Guo F, Sigua C, Vishvanath A, Fiskus W, Scuto A, Annavarapu S, Moscinski L, Bhalla K. George P, et al. Among authors: bhalla k. Cancer Res. 2004 May 15;64(10):3645-52. doi: 10.1158/0008-5472.CAN-04-0006. Cancer Res. 2004. PMID: 15150124

7

Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells.

Guo F, Sigua C, Bali P, George P, Fiskus W, Scuto A, Annavarapu S, Mouttaki A, Sondarva G, Wei S, Wu J, Djeu J, Bhalla K. Guo F, et al. Among authors: bhalla k. Blood. 2005 Feb 1;105(3):1246-55. doi: 10.1182/blood-2004-05-2041. Epub 2004 Sep 23. Blood. 2005. PMID: 15388581 Free article.

8

Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.

George P, Bali P, Annavarapu S, Scuto A, Fiskus W, Guo F, Sigua C, Sondarva G, Moscinski L, Atadja P, Bhalla K. George P, et al. Among authors: bhalla k. Blood. 2005 Feb 15;105(4):1768-76. doi: 10.1182/blood-2004-09-3413. Epub 2004 Oct 28. Blood. 2005. PMID: 15514006 Free article.

9

Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824.

Chen L, Meng S, Wang H, Bali P, Bai W, Li B, Atadja P, Bhalla KN, Wu J. Chen L, et al. Mol Cancer Ther. 2005 Sep;4(9):1311-9. doi: 10.1158/1535-7163.MCT-04-0287. Mol Cancer Ther. 2005. PMID: 16170022

10

Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin.

Guo F, Rocha K, Bali P, Pranpat M, Fiskus W, Boyapalle S, Kumaraswamy S, Balasis M, Greedy B, Armitage ES, Lawrence N, Bhalla K. Guo F, et al. Among authors: bhalla k. Cancer Res. 2005 Nov 15;65(22):10536-44. doi: 10.1158/0008-5472.CAN-05-1799. Cancer Res. 2005. PMID: 16288046

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