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Penicillin sulfone inhibitors of class D beta-lactamases.
Drawz SM, Bethel CR, Doppalapudi VR, Sheri A, Pagadala SR, Hujer AM, Skalweit MJ, Anderson VE, Chen SG, Buynak JD, Bonomo RA. Drawz SM, et al. Among authors: anderson ve. Antimicrob Agents Chemother. 2010 Apr;54(4):1414-24. doi: 10.1128/AAC.00743-09. Epub 2010 Jan 19. Antimicrob Agents Chemother. 2010. PMID: 20086146 Free PMC article.
Role of Asp104 in the SHV beta-lactamase.
Bethel CR, Hujer AM, Hujer KM, Thomson JM, Ruszczycky MW, Anderson VE, Pusztai-Carey M, Taracila M, Helfand MS, Bonomo RA. Bethel CR, et al. Among authors: anderson ve. Antimicrob Agents Chemother. 2006 Dec;50(12):4124-31. doi: 10.1128/AAC.00848-06. Epub 2006 Sep 18. Antimicrob Agents Chemother. 2006. PMID: 16982784 Free PMC article.
Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfone.
Padayatti PS, Sheri A, Totir MA, Helfand MS, Carey MP, Anderson VE, Carey PR, Bethel CR, Bonomo RA, Buynak JD, van den Akker F. Padayatti PS, et al. Among authors: anderson ve. J Am Chem Soc. 2006 Oct 11;128(40):13235-42. doi: 10.1021/ja063715w. J Am Chem Soc. 2006. PMID: 17017804 Free PMC article.
Inhibition of OXA-1 beta-lactamase by penems.
Bethel CR, Distler AM, Ruszczycky MW, Carey MP, Carey PR, Hujer AM, Taracila M, Helfand MS, Thomson JM, Kalp M, Anderson VE, Leonard DA, Hujer KM, Abe T, Venkatesan AM, Mansour TS, Bonomo RA. Bethel CR, et al. Among authors: anderson ve. Antimicrob Agents Chemother. 2008 Sep;52(9):3135-43. doi: 10.1128/AAC.01677-07. Epub 2008 Jun 16. Antimicrob Agents Chemother. 2008. PMID: 18559643 Free PMC article.
Strategic design of an effective beta-lactamase inhibitor: LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone.
Pattanaik P, Bethel CR, Hujer AM, Hujer KM, Distler AM, Taracila M, Anderson VE, Fritsche TR, Jones RN, Pagadala SR, van den Akker F, Buynak JD, Bonomo RA. Pattanaik P, et al. Among authors: anderson ve. J Biol Chem. 2009 Jan 9;284(2):945-53. doi: 10.1074/jbc.M806833200. Epub 2008 Oct 27. J Biol Chem. 2009. PMID: 18955486 Free PMC article.
Identification of a new allelic variant of the Acinetobacter baumannii cephalosporinase, ADC-7 beta-lactamase: defining a unique family of class C enzymes.
Hujer KM, Hamza NS, Hujer AM, Perez F, Helfand MS, Bethel CR, Thomson JM, Anderson VE, Barlow M, Rice LB, Tenover FC, Bonomo RA. Hujer KM, et al. Among authors: anderson ve. Antimicrob Agents Chemother. 2005 Jul;49(7):2941-8. doi: 10.1128/AAC.49.7.2941-2948.2005. Antimicrob Agents Chemother. 2005. PMID: 15980372 Free PMC article.
258 results