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Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry.
Wang L, Cherian C, Desmoulin SK, Polin L, Deng Y, Wu J, Hou Z, White K, Kushner J, Matherly LH, Gangjee A. Wang L, et al. Among authors: deng y. J Med Chem. 2010 Feb 11;53(3):1306-18. doi: 10.1021/jm9015729. J Med Chem. 2010. PMID: 20085328 Free PMC article.
Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry.
Deng Y, Zhou X, Kugel Desmoulin S, Wu J, Cherian C, Hou Z, Matherly LH, Gangjee A. Deng Y, et al. J Med Chem. 2009 May 14;52(9):2940-51. doi: 10.1021/jm8011323. J Med Chem. 2009. PMID: 19371039 Free PMC article.
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